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항염증제제가 실험적 증식치료 모델의 조직 소견에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.date.accessioned | 2015-06-10T12:13:36Z | - |
dc.date.available | 2015-06-10T12:13:36Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1225-584X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109417 | - |
dc.description.abstract | Objective: To investigate the effects of nonsteroidal anti- inflammatory drugs (NSAIDs) and acetaminophen on histologic changes of the Achilles tendon in an experimental prolotherapy model. Method: The right Achilles tendon of 60 rats was injected with 20% dextrose on experimental day 1, 7, and day 14, whereas the left was not injected and used as control. Rats were divided into 3 subgroups: NSAIDs medication group (10 mg/kg/day), acetaminophen medication group (100 mg/ kg/day) and no medication group. Medications were given for 3 consecutive days after each injection. Rats were sacrificed at 3 and 6 weeks after first injection. The transverse diameter of gross specimen, the number of fibroblasts on light microscope, and the distribution of collagen fibril on electron microscope were assessed. Results: The transverse diameter and the count of fibroblasts of all groups increased significantly in the injected tendon compared to the non-injected tendon. However, there were no differences among all groups significantly (p<0.05). On electron micrograph, fibril diameters of injected tendon consisted of mainly smaller sizes with the intermediate sizes. Conclusion: Prolotherapy enhances fibroblastic stimulation and elaboration of extracellular matrix. Short term use of NSAIDs may not have any adverse effects on tissue proliferation after prolotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 378~384 | - |
dc.relation.isPartOf | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 항염증제제가 실험적 증식치료 모델의 조직 소견에 미치는 영향 | - |
dc.title.alternative | The Effects of Anti-inflammatory Drugs on Histologic Findings of the Experimental Prolotherapy Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | 김현정 | - |
dc.contributor.googleauthor | 김세훈 | - |
dc.contributor.googleauthor | 윤동환 | - |
dc.contributor.googleauthor | 이강식 | - |
dc.contributor.googleauthor | 정태석 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00610 | - |
dc.relation.journalcode | J01803 | - |
dc.subject.keyword | Prolotherapy | - |
dc.subject.keyword | Nonsteroidal anti-inflammatory drugs | - |
dc.subject.keyword | Acetaminophen | - |
dc.subject.keyword | Tendon | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 384 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.30(4) : 378-384, 2006 | - |
dc.identifier.rimsid | 57372 | - |
dc.type.rims | ART | - |
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