158 251

Cited 0 times in

제5요후근을 절단한 백서에서 제5요척수신경의 신경손상이나 전기자극에 의한 기계적 과민통 생성에 있어서 말초 글루타민산 수용기의 역할

Other Titles
 Role of Peripheral Glutamate Receptors to Mechanical Hyperalgesia following Nerve Injury or Antidromic Stimulation of L5 Spinal Nerve in Rats with the Previous L5 Dorsal Rhizotomy 
 장준호  ;  남택상  ;  윤덕미  ;  임중우  ;  백광세 
 Korean Journal of Pain (대한통증학회지), Vol.19(1) : 33-44, 2006 
Journal Title
 Korean Journal of Pain (대한통증학회지) 
Issue Date
electrical stimulation ; glutamate ; injury discharge ; nerve injury ; neuropathic pain
Background: Peripheral nerve injury leads to neuropathic pain, including mechanical hyperalgesia (MH). Nerve discharges produced by an injury to the primary afferents cause the release of glutamate from both central and peripheral terminals. While the role of centrally released glutamate in MH has been well studied, relatively little is known about its peripheral role. This study was carried out to determine if the peripherally conducting nerve impulses and peripheral glutamate receptors contribute to the generation of neuropathic pain. Methods: Rats that had previously received a left L5 dorsal rhizotomy were subjected to a spinal nerve lesion (SNL) or brief electrical stimulation (ES, 4 Hz pulses for 5 min) of the left L5 spinal nerve. The paw withdrawal threshold (PWT) to von Frey filaments was measured. The effects of an intraplantar (i.pl.) injection of a glutamate receptor (GluR) antagonist or agonist on the changes in the SNL- or ES-produced PWT was investigated. Results: SNL produced MH, as evidenced by decrease in the PWT, which lasted for more than 42 days. ES also produced MH lasting for 7 days. MK-801 (NMDAR antagonist), DL-AP3 (group-I mGluR antagonist), and APDC (group-II mGluR agonist) delayed the onset of MH when an i.pl. injection was given before SNL. The same application blocked the onset of ES-induced MH. NBQX (AMPA receptor antagonist) had no effect on either the SNL- or ES-induced onset of MH. When drugs were given after SNL or ES, MK-801 reversed the MH, whereas NBQX, DL-AP3, and APDC had no effect. Conclusions: Peripherally conducting impulses play an important role in the generation of neuropathic pain, which is mediated by the peripheral glutamate receptors
Files in This Item:
T200600446.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
Paik, Kwang Se(백광세)
Yoon, Duck Mi(윤덕미)
Leem, Joong Woo(임중우) ORCID logo https://orcid.org/0000-0002-1605-2230
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.