Cited 31 times in
Accumulation of β-catenin protein, mutations in exon-3 of the β-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김호근 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 최승훈 | - |
dc.contributor.author | 박기청 | - |
dc.date.accessioned | 2015-06-10T12:05:34Z | - |
dc.date.available | 2015-06-10T12:05:34Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109176 | - |
dc.description.abstract | BACKGROUND: Solid pseudopapillary tumors (SPT) of the pancreas are neoplasms with a low malignant potential. The molecular events contributing to the pathogenesis of SPTs are still unknown. OBJECTIVES: This study was intended to help better understand the early steps of human SPT development. METHODS: We microdissected 20 SPTs and normal pancreatic tissue. In addition, we examined the DNA from each SPT for mutations in exon-3 of beta-catenin and loss of heterozygosity (LOH) on 9 chromosome arms using 10 microsatellite markers. Immunohistochemical staining for beta-catenin was performed. RESULTS: Activating mutations between codons 32 and 37 of beta-catenin exon-3 were present in 16 cases (80%). Allelic loss on chromosome 5q22.1 was present in 10 cases (55.5%), while no allelic loss was found on chromosomes 1p, 6q, 9p, 9q, 11p, 11q, 17p, or 22q. Nuclear accumulation of beta-catenin was found in 20 cases (100%). CONCLUSION: Mutations in exon-3 of the beta-catenin gene, nuclear accumulation of beta-catenin, and LOH on chromosome 5q22.1 in SPT tissue suggest that these mutations are involved in SPT tumorigenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Carcinoma, Papillary/genetics* | - |
dc.subject.MESH | Carcinoma, Papillary/pathology | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Chromosomes, Human, Pair 5/genetics* | - |
dc.subject.MESH | Cystadenoma, Papillary | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | Exons/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Loss of Heterozygosity* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microsatellite Repeats | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Pancreatic Neoplasms/genetics* | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology | - |
dc.subject.MESH | beta Catenin/genetics* | - |
dc.title | Accumulation of β-catenin protein, mutations in exon-3 of the β-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Seong Min Kim | - |
dc.contributor.googleauthor | Chuan Dong Sun | - |
dc.contributor.googleauthor | Ki Chung Park | - |
dc.contributor.googleauthor | Ho Guen Kim | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Seung Hoon Choi | - |
dc.identifier.doi | 10.1002/jso.20509 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A04103 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 16967453 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jso.20509/abstract | - |
dc.subject.keyword | solid pseudopapillary tumor | - |
dc.subject.keyword | pancreas | - |
dc.subject.keyword | mutation | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | loss of heterozygosity | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.alternativeName | Choi, Seung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Choi, Seung Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 94 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 418 | - |
dc.citation.endPage | 425 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.94(5) : 418-425, 2006 | - |
dc.identifier.rimsid | 55741 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.