Cited 0 times in
세로토닌 수송체와 약물치료
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세주 | - |
dc.contributor.author | 김찬형 | - |
dc.date.accessioned | 2015-06-10T12:05:31Z | - |
dc.date.available | 2015-06-10T12:05:31Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1017-5717 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109174 | - |
dc.description.abstract | The serotonin transporter (SERT) is the target site for serotonin reuptake inhibitors, which are the most widely used agents for treating various psychiatric diseases including depression. The SERT is a member of a large family of homologous integral membrane proteins. This transporter takes up 5-HT in a process that is coupled to the transmembrane movement of Na?, Cl?, and K?. The SERT may operate in at least two modes, an alternating access carrier or a channel. The function of SERT is acutely regulated by various protein kinases and phosphatases. The SERT gene is located on chromosome 17 and has several polymorphisms including 5-HTTLPR and intron 2 VNTR. Most studies involving the association between 5-HTTLPR and the response to SSRI in depression reported that 1/1 genotype showed better response and fewer side effects. But, it is too early to draw definite conclusion of the effects of 5-HTTLPR on anti-depressant treatment. Therefore, it is necessary to perform further studies reflecting various ethnicities and genetics of subjects as well as the environmental interactions. This review discusses recent advances in defining the structure, the action mechanism, the location, and the regulation of SERT. Furthermore, it discusses the function of SERT polymorphisms and its implications on the anti-depressant therapies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 263~272 | - |
dc.relation.isPartOf | Korean Journal of Psychopharmacology (대한정신약물학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 세로토닌 수송체와 약물치료 | - |
dc.title.alternative | Serotonin Transporter and Pharmacotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | 김세주 | - |
dc.contributor.googleauthor | 석정호 | - |
dc.contributor.googleauthor | 김찬형 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01036 | - |
dc.relation.journalcode | J02107 | - |
dc.subject.keyword | Serotonin transporter | - |
dc.subject.keyword | Fuction of SERT | - |
dc.subject.keyword | 5-HTTLPR | - |
dc.subject.keyword | Anti-depressant response | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Kim, Chan Hyung | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Kim, Chan Hyung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 263 | - |
dc.citation.endPage | 272 | - |
dc.identifier.bibliographicCitation | Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.17(3) : 263-272, 2006 | - |
dc.identifier.rimsid | 55739 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.