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Preparation of poly epsilon-caprolactone nanoparticles containing magnetite for magnetic drug carrier

Authors
 J. Yang  ;  S.-B. Park  ;  Ho-Geun Yoon  ;  Y.-M. Huh  ;  S. Haam 
Citation
 International Journal of Pharmaceutics, Vol.324(2) : 185-190, 2006 
Journal Title
 International Journal of Pharmaceutics 
ISSN
 0378-5173 
Issue Date
2006
MeSH
Cisplatin/administration & dosage ; Cisplatin/chemistry ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/chemistry ; Drug Carriers* ; Magnetics* ; Microscopy, Electron, Scanning ; Nanoparticles* ; Particle Size ; Polyesters/administration & dosage* ; Polyesters/chemistry ; Solubility ; Spectroscopy, Fourier Transform Infrared
Keywords
Poly ɛ-caprolactone ; Magnetite ; Emulsion ; Nanoparticle ; Magnetic drug targeting
Abstract
Magnetic poly ɛ-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.
Full Text
http://www.sciencedirect.com/science/article/pii/S0378517306004534
DOI
10.1016/j.ijpharm.2006.06.029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109172
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