Cited 12 times in
Neoplastic transformation and tumorigenesis associated with overexpression of imup-1 and imup-2 genes in cultured NIH/3T3 mouse fibroblasts
DC Field | Value | Language |
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dc.contributor.author | 안정용 | - |
dc.date.accessioned | 2015-06-10T12:04:01Z | - |
dc.date.available | 2015-06-10T12:04:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109129 | - |
dc.description.abstract | Immortalization-upregulated protein 1 (IMUP-1) and immortalization-upregulated protein 2 (IMUP-2) genes have been recently cloned and are known to be involved in SV40-mediated immortalization. IMUP-1 and IMUP-2 genes were strongly expressed in various cancer cell lines and tumors, suggesting the possibility that they might be involved in tumorigenicity. To directly elucidate the functional role of IMUP-1 and IMUP-2 on neoplastic transformation and tumorigenicity, we stably transfected IMUP-1 and IMUP-2 into NIH/3T3 mouse fibroblast cells. Cellular characteristics of the neoplastic transformation were assessed by transformation foci, growth in soft agar, and tumor development in nude mice. We found that IMUP-1 and IMUP-2 overexpressing cells showed altered growth properties, anchorage-independent growth in soft agar and inducing tumor in nude mice. Furthermore, IMUP-1 and IMUP-2 transformants proliferated in reduced serum and shortened cell cycle. These results suggest that ectopic overexpression of IMUP-1 and IMUP-2 may play an important role in acquiring a transformed phenotype, tumorigenicity in vivo, and be related to cellular proliferation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 995~1002 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 3T3 Cells | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cell Transformation, Neoplastic/genetics | - |
dc.subject.MESH | Cell Transformation, Neoplastic/metabolism* | - |
dc.subject.MESH | Cell Transformation, Neoplastic/pathology* | - |
dc.subject.MESH | Culture Media | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblasts | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Genetic Vectors/genetics | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Nuclear Proteins/genetics | - |
dc.subject.MESH | Nuclear Proteins/metabolism* | - |
dc.subject.MESH | Serum | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.title | Neoplastic transformation and tumorigenesis associated with overexpression of imup-1 and imup-2 genes in cultured NIH/3T3 mouse fibroblasts | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Zae Young Ryoo | - |
dc.contributor.googleauthor | Boo Kyoung Jung | - |
dc.contributor.googleauthor | Sang Ryeul Lee | - |
dc.contributor.googleauthor | Myoung Ok Kim | - |
dc.contributor.googleauthor | Sung Hyun Kim | - |
dc.contributor.googleauthor | Hyo Jin Kim | - |
dc.contributor.googleauthor | Jung Yong Ahn | - |
dc.contributor.googleauthor | Tae-Hoon Lee | - |
dc.contributor.googleauthor | Youl Hee Cho | - |
dc.contributor.googleauthor | Jae Hak Park | - |
dc.contributor.googleauthor | Jin Kyeoung Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.08.137 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02260 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16962562 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X06019401 | - |
dc.subject.keyword | IMUP-1 | - |
dc.subject.keyword | IMUP-2 | - |
dc.subject.keyword | SV40 | - |
dc.subject.keyword | Tumorigenicity | - |
dc.subject.keyword | Fibroblast | - |
dc.contributor.alternativeName | Ahn, Jung Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Jung Yong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 349 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 995 | - |
dc.citation.endPage | 1002 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.349(3) : 995-1002, 2006 | - |
dc.identifier.rimsid | 50607 | - |
dc.type.rims | ART | - |
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