Cited 25 times in
Combined Sustained Delivery of Basic Fibroblast Growth Factor and Administration of Granulocyte Colony-Stimulationg Factor
DC Field | Value | Language |
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dc.contributor.author | 유경종 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2015-06-10T12:02:32Z | - |
dc.date.available | 2015-06-10T12:02:32Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1526-6028 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109085 | - |
dc.description.abstract | Purpose: To investigate whether the efficacy of a single angiogenic therapy (sustained delivery of basic fibroblast growth factor [bFGF] or administration of granulocyte colony-stimulating factor [G-CSF]) can be enhanced further by combining the therapies. Methods: One day after surgical induction of hind-limb ischemia, groups of 6 mice were randomized to receive either no treatment, sustained delivery (SD) of bFGF, endothelial progenitor cell (EPC) mobilization with G-CSF administration, or a combination of bFGF SD+G-CSF administration. Results: G-CSF administration increased significantly (p<0.05) the number of EPC lineages (CD34+/AC133+ cells) in both peripheral blood and bone marrow compared to no G-CSF administration. The bFGF SD and G-CSF administration individually increased the capillary and arteriole densities significantly versus no treatment (capillary density: 659±48/mm2 and 385±59/mm2, respectively, versus 280±28/mm2; p<0.05; arteriole density: 34±9/mm2 and 41±6/mm2, respectively, versus 15±2/mm2; p<0.05). Importantly, bFGF SD+G-CSF further increased the capillary and arteriole densities compared to either strategy alone (capillary density: 786±40/mm2 versus 659±48/mm2 and 385±59/mm2, respectively, p<0.05; arteriole density: 55±10/mm2 versus 34±9/mm2 and 41±6/mm2, respectively, p<0.05). Conclusion: This study demonstrates that the combined therapy of sustained bFGF delivery and G-CSF administration potentiates the angiogenic efficacy of either single therapy in mouse hind-limb ischemia models. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 175~181 | - |
dc.relation.isPartOf | JOURNAL OF ENDOVASCULAR THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Drug Synergism | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblast Growth Factor 2/administration & dosage* | - |
dc.subject.MESH | Fibroblast Growth Factor 2/pharmacology | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Granulocyte Colony-Stimulating Factor/administration & dosage* | - |
dc.subject.MESH | Granulocyte Colony-Stimulating Factor/pharmacology | - |
dc.subject.MESH | Hindlimb/blood supply* | - |
dc.subject.MESH | Ischemia/drug therapy* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Neovascularization, Physiologic/drug effects* | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.title | Combined Sustained Delivery of Basic Fibroblast Growth Factor and Administration of Granulocyte Colony-Stimulationg Factor | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Oju Jeon | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Kyung-Jong Yoo | - |
dc.contributor.googleauthor | Byung-Soo Kim | - |
dc.identifier.doi | 10.1583/05-1713MR.1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J01395 | - |
dc.identifier.eissn | 1545-1550 | - |
dc.identifier.pmid | 16643071 | - |
dc.identifier.url | http://jevtonline.org/doi/abs/10.1583/05-1713MR.1 | - |
dc.subject.keyword | mouse model | - |
dc.subject.keyword | limb ischemia model | - |
dc.subject.keyword | angiogenic therapy | - |
dc.subject.keyword | basic fibroblast growth factor | - |
dc.subject.keyword | endothelial progenitor cell mobilization | - |
dc.subject.keyword | granulocyte colony-stimulating factor | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 175 | - |
dc.citation.endPage | 181 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENDOVASCULAR THERAPY, Vol.13(2) : 175-181, 2006 | - |
dc.identifier.rimsid | 50573 | - |
dc.type.rims | ART | - |
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