Cited 21 times in
Granulocyte colony-stimulating factor treatment enhances the efficacy of cellular cardiomyoplasty with transplantation of embryonic stem cell-derived cardiomyocytes in infarcted myocardium
DC Field | Value | Language |
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dc.contributor.author | 유경종 | - |
dc.date.accessioned | 2015-06-10T12:02:28Z | - |
dc.date.available | 2015-06-10T12:02:28Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109083 | - |
dc.description.abstract | We tested the hypothesis that granulocyte colony-stimulating factor (G-CSF) administration would enhance the efficacy of cellular cardiomyoplasty with embryonic stem (ES) cell-derived cardiomyocytes in infarcted myocardium. Three weeks after myocardial infarction by cryoinjury, Sprague–Dawley rats were randomized to receive either an injection of medium, ES cell-derived cardiomyocyte transplantation, G-CSF administration, or a combination of G-CSF administration and ES cell-derived cardiomyocyte transplantation. Eight weeks after treatment, the cardiac tissue formation, neovascularization, and apoptotic activity in the infarct regions were evaluated by histology and immunohistochemistry. The left ventricular (LV) dimensions and function of the treated heart were evaluated by echocardiography. Transplanted ES cell-derived cardiomyocytes survived and participated in the myocardial regeneration in the infarcted heart. A combination of G-CSF treatment and ES cell-derived cardiomyocyte transplantation significantly promoted angiogenesis and reduced the infarct area and cell apoptosis in the infarcted myocardium compared with ES cell-derived cardiomyocyte transplantation alone. The combination therapy also attenuated LV dilation, as compared with ES cell-derived cardiomyocyte transplantation alone. G-CSF treatment can enhance the efficacy of cellular cardiomyoplasty by ES cell-derived cardiomyocyte transplantation to treat myocardial infarction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 573~582 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cardiomyoplasty* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Embryo, Mammalian/cytology | - |
dc.subject.MESH | Granulocyte Colony-Stimulating Factor/pharmacology* | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Myocardial Infarction/drug therapy* | - |
dc.subject.MESH | Myocardial Infarction/pathology | - |
dc.subject.MESH | Myocardial Infarction/surgery* | - |
dc.subject.MESH | Myocytes, Cardiac/cytology | - |
dc.subject.MESH | Myocytes, Cardiac/transplantation* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Stem Cell Transplantation* | - |
dc.title | Granulocyte colony-stimulating factor treatment enhances the efficacy of cellular cardiomyoplasty with transplantation of embryonic stem cell-derived cardiomyocytes in infarcted myocardium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Seung-Woo Cho | - |
dc.contributor.googleauthor | So-Jung Gwak | - |
dc.contributor.googleauthor | Il-Kwon Kim | - |
dc.contributor.googleauthor | Myeong-Chan Cho | - |
dc.contributor.googleauthor | Kyung-Kuk Hwang | - |
dc.contributor.googleauthor | Jin-Sook Kwon | - |
dc.contributor.googleauthor | Cha Yong Choi | - |
dc.contributor.googleauthor | Kyung Jong Yoo | - |
dc.contributor.googleauthor | Byung-Soo Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.12.044 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02453 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16376856 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X05027439 | - |
dc.subject.keyword | Embryonic stem cell-derived cardiomyocyte | - |
dc.subject.keyword | Granulocyte colony-stimulating factor | - |
dc.subject.keyword | Myocardial infarction | - |
dc.subject.keyword | Neovascularization | - |
dc.subject.keyword | Myocardial regeneration | - |
dc.subject.keyword | Cellular cardiomyoplasty | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 340 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 573 | - |
dc.citation.endPage | 582 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.340(2) : 573-582, 2006 | - |
dc.identifier.rimsid | 50572 | - |
dc.type.rims | ART | - |
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