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Ketogenic diet for treatment of infantile spasms

Authors
 So Hee Eun  ;  Hoon Chul Kang  ;  Dong Wook Kim  ;  Heung Dong Kim 
Citation
 BRAIN & DEVELOPMENT, Vol.28(9) : 566-571, 2006 
Journal Title
 BRAIN & DEVELOPMENT 
ISSN
 0387-7604 
Issue Date
2006
MeSH
Child, Preschool ; Dietary Carbohydrates/administration & dosage* ; Dietary Fats/administration & dosage* ; Dietary Proteins/administration & dosage* ; Female ; Humans ; Infant ; Ketones/metabolism ; Ketosis/etiology ; Male ; Retrospective Studies ; Spasms, Infantile/drug therapy* ; Treatment Outcome
Keywords
Ketogenic diet ; Infantile spasms ; Electroencephalograms
Abstract
This study sought to evaluate the efficacy, tolerability, and safety of a ketogenic diet (KD) in the treatment of infantile spasms (IS), incorporating a revised protocol based on our previous experience with KD. We undertook a retrospective analysis of 43 children who suffered from catastrophic IS and tried KD from June 1995 to May 2004 in two Korean epilepsy centers. Outcome measures included seizure frequency, electroencephalograms (EEGs), adverse reactions, and neurological development. Overall, the diet achieved the seizure-free state in 53.5% (23/43) of patients and a greater than 90% reduction of seizure frequency in 62.8% (27/43) of patients. The seizure outcomes were highly concordant with improvements in EEG findings and development. In addition, KD could be maintained more safely and more comfortably because of our revised protocol that included an initial non-fasting diet, a short-term trial of 8 months, a more protein-rich diet with a lipid to non-lipid ratio of 3:1, and liquid ketogenic milk. Most complications were transient and KD was well tolerated in most cases. KD can be an effective alternative therapy for catastrophic IS, and additional benefits may be derived from constant revision of the diet in the future.
Full Text
http://www.sciencedirect.com/science/article/pii/S0387760406000866
DOI
10.1016/j.braindev.2006.03.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109054
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