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Activation of Spinal GABA Receptors Attenuates Chronic Central Neuropathic Pain after Spinal Cord Injury

DC FieldValueLanguage
dc.contributor.author남택상-
dc.contributor.author백광세-
dc.contributor.author임중우-
dc.date.accessioned2015-06-10T12:00:42Z-
dc.date.available2015-06-10T12:00:42Z-
dc.date.issued2006-
dc.identifier.issn0897-7151-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109028-
dc.description.abstractIn this study, we investigated the role of the spinal GABAergic system in central neuropathic painlike outcomes following spinal cord injury (SCI) produced by a spinal hemitransection at T13 of the rat. After SCI, mechanical allodynia develops bilaterally in both hind paws of the rat, lasting longer than 40 days, as evidenced by an increase in paw withdrawal frequency in response to a weak von Frey filament. In naive rats, intrathecal (i.t.) administration in the lumbar spinal cord of GABAA and GABAB receptor antagonists, bicuculline (1-5 microg) and phaclofen (0.1-5 microg), respectively, causes a dose-dependent increase in the magnitude of mechanical allodynia. The SCI-induced mechanical allodynia in both hind-paws is attenuated by i.t. administration in the lumbar spinal cord of GABAA or GABAB receptor agonists, muscimol (1 microg) or baclofen (0.5 microg), respectively. In electrophysiological experiments, rats with SCI show a bilateral increase in hyperexcitability in response to natural stimuli in wide dynamic range (WDR) neurons in the lumbar spinal dorsal horn. The topical application of muscimol (1 microg) or baclofen (0.5 microg) onto the lumbar cord surface reduce the SCIinduced increased responsiveness of WDR neurons. Inhibitory effects of muscimol and baclofen on both the behavioral mechanical allodynia and the hyperexcitability in WDR neuron with SCI compared to controls, were antagonized by pre-treatment of bicuculline (10 microg) and phaclofen (5 microg), respectively. This study provides behavioral and electrophysiological evidence for the important role of the loss of spinal inhibitory tone, mediated by activation of both GABAA and GABAB receptors, in the development of central neuropathic pain following SCI.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1111~1124-
dc.relation.isPartOfJOURNAL OF NEUROTRAUMA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHGABA Antagonists/pharmacology-
dc.subject.MESHMale-
dc.subject.MESHPain/etiology-
dc.subject.MESHPain/metabolism*-
dc.subject.MESHPain/prevention & control-
dc.subject.MESHPain Measurement/drug effects-
dc.subject.MESHPain Measurement/methods-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, GABA/metabolism*-
dc.subject.MESHSpinal Cord/drug effects-
dc.subject.MESHSpinal Cord/metabolism*-
dc.subject.MESHSpinal Cord Injuries/complications-
dc.subject.MESHSpinal Cord Injuries/metabolism*-
dc.titleActivation of Spinal GABA Receptors Attenuates Chronic Central Neuropathic Pain after Spinal Cord Injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.googleauthorYoung Seob Gwak-
dc.contributor.googleauthorHuai Yu Tan-
dc.contributor.googleauthorTaick Sang Nam-
dc.contributor.googleauthorKwang Se Paik-
dc.contributor.googleauthorClaire E. Hulsebosch-
dc.contributor.googleauthorJoong Woo Leem-
dc.identifier.doi10.1089/neu.2006.23.1111-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01271-
dc.contributor.localIdA01817-
dc.contributor.localIdA03409-
dc.relation.journalcodeJ01640-
dc.identifier.eissn1557-9042-
dc.identifier.pmid16866624-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/neu.2006.23.1111-
dc.subject.keywordbaclofen-
dc.subject.keywordcentral neuropathic pain-
dc.subject.keywordHemitransection-
dc.subject.keywordmuscimol-
dc.subject.keywordspinal cord injury-
dc.subject.keywordwide dynamic range neuron-
dc.contributor.alternativeNameNam, Taick Sang-
dc.contributor.alternativeNamePaik, Kwang Se-
dc.contributor.alternativeNameLeem, Joong Woo-
dc.contributor.affiliatedAuthorNam, Taick Sang-
dc.contributor.affiliatedAuthorPaik, Kwang Se-
dc.contributor.affiliatedAuthorLeem, Joong Woo-
dc.rights.accessRightsnot free-
dc.citation.volume23-
dc.citation.number7-
dc.citation.startPage1111-
dc.citation.endPage1124-
dc.identifier.bibliographicCitationJOURNAL OF NEUROTRAUMA, Vol.23(7) : 1111-1124, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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