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Intraoperative examination of sentinel lymph nodes by immunohistochemical staining in patients with breast cancer

 I.-K. Lee  ;  H.-D. Lee  ;  J. Jeong  ;  B.-W. Park  ;  W.H. Jung  ;  S.W. Hong  ;  K.K. Oh  ;  Y.H. Ryu 
 EJSO, Vol.32(4) : 405-409, 2006 
Journal Title
Issue Date
Adult ; Aged ; Axilla ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology* ; Breast Neoplasms/surgery ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Intraoperative Care/methods ; Keratins/metabolism ; Lymph Node Excision* ; Lymph Nodes/metabolism ; Lymph Nodes/pathology* ; Middle Aged ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy*
Breast cancer ; Sentinel lymph node ; H&E stained frozen section ; Rapid cytokeratin immunochemistry (CK-IHC)
AIM: To performed a prospective investigation of the relative merits of rapid cytokeratin immunohistochemical (CK-IHC) staining of the SLN removed during the operation of breast cancer patients. STUDY DESIGN: Between December 2002 and March 2004, 62 patients with T1 and T2 breast cancer were enrolled after undergoing successful sentinel lymph node biopsy. Eighty-nine sentinel lymph nodes (mean number, 1.44) were biopsied and first examined by hematoxylin-eosin (H&E) stained frozen section. All the tumour free sentinel lymph nodes by H&E stained frozen section were immunostained for cytokeratin using a rapid immunohistochemical assay (Cytokeratin (PAN), 1:50, Novocastra Lab., Newcastle, UK) during the operations. RESULTS: Rapid IHC staining revealed seven positive sentinel lymph nodes that were negative for metastasis by H&E staining. This study showed a sensitivity of 92.86%, a specificity of 100%, an accuracy of 98.9%, and a negative predictive value of 98.7%. CONCLUSIONS: The intraoperative examination of sentinel lymph nodes is an accurate and effective way of predicting the axillary lymph node status of patients with breast cancers.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Lee, Hy De(이희대)
Jung, Woo Hee(정우희)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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