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The role of postoperative external-beam radiotherapy in the management of patients with papillary thyroid cancer invading the trachea

Authors
 Ki Chang Keum  ;  Yang Gun Suh  ;  Woong Sub Koom  ;  Jae Ho Cho  ;  Su Jung Shim  ;  Chang Geol Lee  ;  Chung Soo Park  ;  Woong Youn Chung  ;  Gwi Eon Kim 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.65(2) : 474-480, 2006 
Journal Title
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 
ISSN
 0360-3016 
Issue Date
2006
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Papillary/mortality ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/radiotherapy* ; Carcinoma, Papillary/surgery ; Case-Control Studies ; Chi-Square Distribution ; Female ; Humans ; Iodine Radioisotopes/therapeutic use ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Proportional Hazards Models ; Retrospective Studies ; Survival Rate ; Thyroid Neoplasms/mortality ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/radiotherapy* ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods ; Tracheal Neoplasms/mortality ; Tracheal Neoplasms/pathology ; Tracheal Neoplasms/radiotherapy*
Keywords
Thyroid cancer ; Tracheal invasion ; External-beam radiotherapy
Abstract
Purpose: To determine the role of adjuvant external-beam radiotherapy (EBRT) in the management of patients with well-differentiated thyroid cancer invading the trachea. Methods and Materials: Of 1,098 thyroid cancer patients, 68 (6%) were found to have tracheal invasion, and they all received “shave” excision of the tracheal cartilage. Among them, 12 patients had no postoperative residuum, 43 patients had microscopic residuum, and 13 patients had macroscopic residuum. All patients were divided into two groups according to treatment modality with or without EBRT; (1) the control group (n = 43) and (2) the EBRT group (n = 25). Results: The locoregional recurrence rate for EBRT patients was much lower than that of control patients (51% for the control group vs. 8% for the EBRT group) (p < 0.01). The 10-year local progression-free survival rate for the EBRT group was significantly better than that of the control group (89% in the EBRT group vs. 38% in the control group) (log–rank, p < 0.01). The use of adjuvant EBRT after conservative surgery was an independent prognostic factor in univariate and multivariate analyses. Conclusions: External-beam radiotherapy was found to be effective, particularly in patients with thyroid cancer invading the trachea with microscopic or gross residuum after conservative surgery.
Full Text
http://www.sciencedirect.com/science/article/pii/S0360301605030762
DOI
10.1016/j.ijrobp.2005.12.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Gwi Eon(김귀언)
Park, Cheong Soo(박정수)
Shim, Su Jung(심수정)
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
Chung, Woong Youn(정웅윤)
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108873
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