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Comparison of corneal thickness after the instillation of topical anesthetics - Proparacaine versus oxybuprocaine

 Sang Min Nam  ;  Hyung Keun Lee  ;  Eung Kweon Kim  ;  Kyoung Yul Seo 
 CORNEA, Vol.25(1) : 51-54, 2006 
Journal Title
Issue Date
Adult ; Anesthetics, Local/administration & dosage* ; Body Weights and Measures ; Cornea/drug effects* ; Cornea/physiopathology ; Corneal Edema/chemically induced* ; Corneal Edema/physiopathology ; Female ; Humans ; Male ; Procaine/administration & dosage ; Procaine/analogs & derivatives* ; Propoxycaine/administration & dosage* ; Time Factors
cornea ; oxybuprocaine ; proparacaine ; thickness
PURPOSE: To compare changes in human corneal thickness after the instillation of proparacaine with those after oxybuprocaine instillation with time over a period of 10 minutes. METHODS: Eighteen healthy young participants were recruited. Proparacaine was used in the right eye and oxybuprocaine in the left. Right and left baseline corneal thicknesses were measured every 30 seconds for 10 minutes using a noncontact specular microscope by 1 observer. Baseline corneal thickness was defined as the average of all values taken over 10 minutes. Changes in corneal thickness were measured every 20 seconds for 10 minutes after the administration of 1 drop of 0.5% proparacaine onto the right cornea and 1 drop of 0.4% oxybuprocaine onto the left cornea. RESULTS: Mean baseline right cornea thickness was 531 +/- 45 microm, and that of the left cornea was 531 +/- 42 microm. The corneal thickness after proparacaine increased by 8.6 microm ( approximately 4.5-12.6 microm, 95% CI) and then returned to baseline within 80 seconds. Corneal thickness after applying oxybuprocaine increased by 7.7 microm (3.6-11.2 microm, 95% CI) and then returned to baseline within 80 seconds. There was a second transient increase about 5 minutes later after proparacaine instillation but no additional transient increase after oxybuprocaine instillation. CONCLUSION: Oxybuprocaine is similar to proparacaine in terms of the severity of its effect on corneal thickness. Corneal thickness instability may occur for 5 minutes after proparacaine administration. Changes in corneal thickness after topical anesthetic instillation should be considered when performing measurements for refractive surgery or central corneal thickness in glaucoma patients.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
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