1 261

Cited 5 times in

Comparison of stage-specific outcome of breast cancer based on 5th and 6th AJCC staging system

 Seung Il Kim  ;  Byeong Woo Park  ;  Kyong Sik Lee 
 JOURNAL OF SURGICAL ONCOLOGY, Vol.93(3) : 221-227, 2006 
Journal Title
Issue Date
Breast Neoplasms/mortality* ; Breast Neoplasms/pathology* ; Disease-Free Survival ; Humans ; Neoplasm Staging* ; Retrospective Studies ; Treatment Outcome
breast cancer ; staging system ; nodal involvement ; survival
BACKGROUND AND OBJECTIVES: To investigate the appropriateness of the new staging system (AJCC 6th edition) for breast carcinoma. METHODS: We reviewed the clinicopathologic data of 1,768 breast cancer patients, and their disease stages were re-categorized by the new system. The overall survival (OS) and distant relapse free survival (DRFS) rates were compared between those patients whose stages by the old system (AJCC 5th edition) remained the same (the remainders) and those patients whose stages moved up (the upstaged cases) as well as between the subgroups in the new system. RESULTS: The 10-year DRFS rates of the upstaged cases in each stage were poorer than those of the remainders, and statistical significance was demonstrated for stage IIB and stage IIIA. The 10-year OS rates were also poorer in the upstaged cases, and statistical significance was demonstrated for stage IIIA. Subgroup analysis within the new system between the node-negative versus node-positive subgroups in stages IIA and IIB showed a significant OS difference. The DRFS difference was also shown between the subgroups in stage IIA. CONCLUSIONS: The new staging system seems to more accurately reflect disease outcome, however, a re-evaluation might be required to reflect the impact of nodal involvement upon the new staging system.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Kim, Seung Il(김승일)
Kim, Joo Hang(김주항)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Kyong Sik(이경식)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.