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아토피피부염 환자에서 독세핀 크림 국소도포요법의 소양증 경감 효과에 대한 연구
DC Field | Value | Language |
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dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이주희 | - |
dc.date.accessioned | 2015-06-10T11:53:00Z | - |
dc.date.available | 2015-06-10T11:53:00Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108793 | - |
dc.description.abstract | ackground: Atopic dermatitis is associated with severe pruritus for which effective topical treatment is lacking. As a potent H1 and H2 antagonist, the antipruritic effect of topical doxepin has been demonstrated in eczematous dermatitis. Objective: We evaluated the efficacy and safety of topical 5% doxepin cream in relieving pruritus associated with atopic dermatitis. Methods: A total of 44 patients with atopic dermatitis, who had moderate to severe daily pruritus for at least 1 week, were enrolled in the double-blind, vehicle-controlled study. Randomly assigned 5% doxepin cream or vehicle cream was applied four times daily for 7 days trial. Results: Relief of pruritus was achieved in 85% of doxepin-treated patients and 57% of vehicle-treated patients by day 7. At each study visit, the physician’s global evaluation for relief of pruritus showed significant improvement in the doxepin treatment group (p < 0.01). Visual analogue scales for pruritus severity and pruritus relief showed similar improvements in the doxepin-treated group. The most common adverse effects reported included localized erythema, xerosis (doxepin group, n=5; vehicle group, n=3) and drowsiness (doxepin group, n=2; vehicle group, n=0). Conclusion: Topical doxepin is effective in reducing pruritus in patients with atopic dermatitis. It has apparently a short-term low risk of major side effects or sensitization. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 아토피피부염 환자에서 독세핀 크림 국소도포요법의 소양증 경감 효과에 대한 연구 | - |
dc.title.alternative | The Antipruritic Effect of Topical Doxepin Cream in Patients with Atopic Dermatitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 이희정 | - |
dc.contributor.googleauthor | 박창욱 | - |
dc.contributor.googleauthor | 이주희 | - |
dc.contributor.googleauthor | 이광훈 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J02000 | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Doxepin cream | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 309 | - |
dc.citation.endPage | 314 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology, Vol.44(3) : 309-314, 2006 | - |
dc.identifier.rimsid | 57705 | - |
dc.type.rims | ART | - |
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