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Factors affecting histological regression of crescentic Henoch-Scho?nlein nephritis in children

Authors
 Jae Il Shin  ;  Jee Min Park  ;  Ji Hong Kim  ;  Jae Seung Lee  ;  Hyeon Joo Jeong 
Citation
 PEDIATRIC NEPHROLOGY, Vol.21(1) : 54-59, 2006 
Journal Title
 PEDIATRIC NEPHROLOGY 
ISSN
 0931-041X 
Issue Date
2006
Keywords
Crescentic Henoch–Schönlein nephritis ; Age ; Early treatment ; Fibrinogen deposition ; Histological regression
Abstract
To identify the factors affecting histological regression of crescentic Henoch–Schönlein nephritis (HSN), we retrospectively analyzed serially biopsied 20 children with crescentic HSN treated with immunosuppressants. They were classified into two groups according to the histological changes between the first and second biopsy: group I (n=10) with histological regression and group II (n=10) with no change or histological progression. Of the 20 patients, 19 showed a favorable outcome at the end of follow-up. Initial laboratory and histological findings did not differ between the two groups. Histological regression was associated with a younger age at onset (P=0.003), early treatment with immunosuppressants (P=0.044) and absent or decreased fibrinogen deposits at the second biopsy (P<0.0001) in a univariate analysis. Mesangial IgA and fibrinogen depositions at the second biopsy were reduced significantly in group I (P<0.05). In the multivariate analysis, a younger age was an independent determinant of histological regression (OR 1.44; 95% CI 1.03–2.02). The intensity of fibrinogen deposits at the second biopsy correlated positively with the age at onset (r=0.503, P=0.024), and the chronicity index at the second biopsy correlated positively with the time that immunosuppressive therapy was started (r=0.619, P=0.004).
Full Text
http://link.springer.com/article/10.1007%2Fs00467-005-2068-5
DOI
10.1007/s00467-005-2068-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Hong(김지홍) ORCID logo https://orcid.org/0000-0001-5352-5423
Lee, Jae Seung(이재승)
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108775
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