Cited 128 times in
[6]-Gingerol Induces Cell Cycle Arrest and Cell Death of Mutant p53-expressing Pancreatic Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | 박승우 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 송시영 | - |
dc.date.accessioned | 2015-06-10T11:51:37Z | - |
dc.date.available | 2015-06-10T11:51:37Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108752 | - |
dc.description.abstract | [6]-Gingerol, a major phenolic compound derived from ginger, has anti-bacterial, anti-inflammatory and anti-tumor activities. While several molecular mechanisms have been described to underlie its effects on cells in vitro and in vivo, the underlying mechanisms by which [6]-gingerol exerts anti-tumorigenic effects are largely unknown. The purpose of this study was to investigate the action of [6]-gingerol on two human pancreatic cancer cell lines, HPAC expressing wild-type (wt) p53 and BxPC-3 expressing mutated p53. We found that [6]-gingerol inhibited the cell growth through cell cycle arrest at G1 phase in both cell lines. Western blot analyses indicated that [6]-gingerol decreased both Cyclin A and Cyclin-dependent kinase (Cdk) expression. These events led to reduction in Rb phosphorylation followed by blocking of S phase entry. p53 expression was decreased by [6]-gingerol treatment in both cell lines suggesting that the induction of Cyclin-dependent kinase inhibitor, p21cip1, was p53-independent. [6]-Gingerol induced mostly apoptotic death in the mutant p53-expressing cells, while no signs of early apoptosis were detected in wild type p53-expressing cells and this was related to the increased phosphorylation of AKT. These results suggest that [6]-gingerol can circumvent the resistance of mutant p53-expressing cells towards chemotherapy by inducing apoptotic cell death while it exerts cytostatic effect on wild type p53-expressing cells by inducing temporal growth arrest. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 688~697 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology* | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Catechols | - |
dc.subject.MESH | Cell Cycle/drug effects* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Drug Resistance, Neoplasm | - |
dc.subject.MESH | Fatty Alcohols/pharmacology* | - |
dc.subject.MESH | Fatty Alcohols/therapeutic use | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Pancreatic Neoplasms/drug therapy* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | Tumor Suppressor Protein p53/genetics* | - |
dc.subject.MESH | Tumor Suppressor Protein p53/metabolism | - |
dc.title | [6]-Gingerol Induces Cell Cycle Arrest and Cell Death of Mutant p53-expressing Pancreatic Cancer Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yon Jung Park | - |
dc.contributor.googleauthor | Jing Wen | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.identifier.doi | 10.3349/ymj.2006.47.5.688 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A02035 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 17066513 | - |
dc.subject.keyword | [6]-gingerol | - |
dc.subject.keyword | pancreatic cancer | - |
dc.subject.keyword | G1 phase | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | AKT | - |
dc.contributor.alternativeName | Park, Seung Woo | - |
dc.contributor.alternativeName | Bang, Seung Min | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Park, Seung Woo | - |
dc.contributor.affiliatedAuthor | Bang, Seung Min | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 688 | - |
dc.citation.endPage | 697 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.47(5) : 688-697, 2006 | - |
dc.identifier.rimsid | 57679 | - |
dc.type.rims | ART | - |
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