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DH-I-180-3-Mediated Photodynamic Therapy: Biodistribution and Tumor Vascular Damage

Authors
 Dae-Seog Lim  ;  Si-Hwan Kol  ;  Chang-Hee Lee  ;  Woong-Shick Ahn  ;  Won-Young Lee 
Citation
 PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol.82(2) : 600-605, 2006 
Journal Title
PHOTOCHEMISTRY AND PHOTOBIOLOGY
ISSN
 0031-8655 
Issue Date
2006
MeSH
Animals ; Chlorophyll/analogs & derivatives ; DNA Fragmentation/drug effects* ; DNA Fragmentation/radiation effects ; Dose-Response Relationship, Drug ; Endothelium, Vascular/drug effects* ; Endothelium, Vascular/pathology ; Light ; Mice ; Neoplasms/drug therapy* ; Neoplasms/metabolism ; Neoplasms/pathology ; Photochemotherapy* ; Photosensitizing Agents/pharmacokinetics ; Photosensitizing Agents/therapeutic use* ; Porphyrins/pharmacokinetics ; Porphyrins/therapeutic use* ; Time Factors ; Tissue Distribution/drug effects ; Tissue Distribution/radiation effects ; Tumor Cells, Cultured
Abstract
An important goal of photodynamic therapy (PDT) for treatment of various cancers is to shorten PDT-performing time and simultaneously enhance PDT efficacy. Here, we investigated the nontumor tissue distribution of and the tumor vascular damage caused by a new photosensitizer, DH-I-180–3, in mice with implanted EMT6 mammary tumor cells. In addition, we performed cell-based assays to evaluate the basic antitumor effect of DH-I-180–3PDT in EMT6 cells. After administration of PDT, the type of cell death was characterized to be apoptosis, and a change in the mitochondrial membrane potential was also observed within minutes. On the other hand, tumor growth was remarkably retarded in vivo in mice that received DH-I-180–3/PDT, compared with mice in the control group, which were exposed to light irradiation alone. Finally, tumors in some mice nearly healed. The antitumor drug reached a maximum concentration approximately 3 h after administration. However, PDT was most effective when there was substantial accumulation of DH-I-180–3 in the tumor vasculature and in healthy tissue. The histological demonstration provided further evidence of tumor vascular damage. On the basis of these findings, we suggest that PDT with the photosensitizer DH-I-180–3 induces vascular damage with blood vessel shutdown, in addition to direct killing of tumor cells, in mice.
Full Text
http://onlinelibrary.wiley.com/doi/10.1562/2005-09-13-RA-683/abstract
DOI
10.1562/2005-09-13-RA-683
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Won Young(이원영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108751
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