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Resveratrol Downregulates Acetyl-CoA Carboxylase α and Fatty Acid Synthase by AMPK-mediated Downregulation of mTOR in Breast Cancer Cells

Authors
 Sahng Wook Park  ;  Sarah Yoon  ;  Jong-Seok Moon  ;  Byeong-Woo Park  ;  Kyung-Sup Kim 
Citation
 FOOD SCIENCE AND BIOTECHNOLOGY, Vol.17(5) : 1047-1051, 2008 
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
ISSN
 1226-7708 
Issue Date
2008
Keywords
resveratrol ; fatty acid synthase ; acetyl-CoA carboxylase ; mammalian target of rapamycin ; AMP-activated protein kinase ; breast cancer
Abstract
Overexpression of HER2 in breast cancer cells is considered to induce the expression of acetyl-CoA carboxylase α (ACACA) and fatty acid synthase (FASN) through activation of mammalian target of rapamycin (mTOR) signaling pathway. Resveratrol, a red wine polyphenol, has been shown to induce apoptosis in several cancers by interfering in several signaling pathways. Present study elucidated the mechanism by which resveratrol downregulates ACACA and FASN in breast cancer cells. Resveratrol activated AMP-activated protein kinase (AMPK) and downregulated mTOR in BT-474 cells. These effects of resveratrol were mimicked by AICAR, an AMPK activator, and exogenously expressed constitutively active AMPK, while they were abolished by a dominant-negative mutant of AMPK. The downregulation of mTOR was not accompanied with changes in Akt, the upstream regulator of mTOR. These findings indicate that the downregulation of ACACA and FASN by resveratrol is mediated by the downregulation of mTOR signaling pathway via activation of AMPK
Full Text
http://www.dbpia.co.kr/Article/1562517
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sup(김경섭) ORCID logo https://orcid.org/0000-0001-8483-8537
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Sahng Wook(박상욱) ORCID logo https://orcid.org/0000-0002-9594-7074
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107712
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