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Diffuse Large B Cell Lymphoma Shows Distinct Methylation Profiles of the Tumor Suppressor Genes among the Non-Hodgkin's Lymphomas.
DC Field | Value | Language |
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dc.contributor.author | 윤선옥 | - |
dc.date.accessioned | 2015-05-19T17:40:50Z | - |
dc.date.available | 2015-05-19T17:40:50Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108610 | - |
dc.description.abstract | BACKGROUND: Aberrant methylation of CpG islands in promoter regions is one of the major mechanisms for silencing of tumor suppressor genes in various types of human cancers including non-Hodgkin's lymphomas (NHL). In this study, we investigated the aberrant promoter methylation status of known or suspected tumor suppressor genes in NHLs and compared the methylation profiles between B-cell and T/NK-cell NHLs. METHODS: 54 cases of B-cell NHLs and 16 cases of T/NK-cell NHLs were examined for the methylation status of eight genes using methylation specific PCR. RESULTS: CpG islands methylation was variously found in eight genes as follows; DAPK (71%), MT1G (70%), p16 (53%), CDH1 (53%), THBS1 (56%), MGMT (27.1%), COX2 (13%), and RUNX3 (11.4%). In six cases (8 %), methylation was not observed in any of these genes. Overall methylation index of B-cell NHLs (0.48) was significantly higher than that of T/NK-cell NHLs (0.32). Of eight genes tested, THBS1 and CDH1 methylations were much more prominent in diffuse large B-cell lymphomas than in T/NK-cell NHLs or other B-cell NHLs. CONCLUSION: This study suggests that aberrant CpG island methylation is a frequent event in NHLs, and diffuse large B-cell lymphomas show overlapping but distinct methylation profiles. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 16~20 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Diffuse Large B Cell Lymphoma Shows Distinct Methylation Profiles of the Tumor Suppressor Genes among the Non-Hodgkin's Lymphomas. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.contributor.googleauthor | Young A Kim | - |
dc.contributor.googleauthor | Yoon Kyung Jeon | - |
dc.contributor.googleauthor | Ji-Eun Kim | - |
dc.contributor.googleauthor | Gyeong Hoon Kang | - |
dc.contributor.googleauthor | Chul Woo Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02566 | - |
dc.relation.journalcode | J02092 | - |
dc.identifier.eissn | 2092-8920 | - |
dc.identifier.pmid | Lymphoma, non-Hodgkin; DNA methylation; Genes, tumor suppressor | - |
dc.subject.keyword | Lymphoma, non-Hodgkin | - |
dc.subject.keyword | DNA methylation | - |
dc.subject.keyword | Genes, tumor suppressor | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 16 | - |
dc.citation.endPage | 20 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY , Vol.42(1) : 16-20, 2008 | - |
dc.identifier.rimsid | 37126 | - |
dc.type.rims | ART | - |
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