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MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type.
DC Field | Value | Language |
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dc.contributor.author | 윤선옥 | - |
dc.date.accessioned | 2015-05-19T17:40:48Z | - |
dc.date.available | 2015-05-19T17:40:48Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108609 | - |
dc.description.abstract | AIMS: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 translocations and copy number changes in adult DLBCLs to evaluate their clinicopathological features and prognostic implications. METHODS AND RESULTS: Gene status was examined using fluorescence in situ hybridization (FISH), and the results were analysed in the context of germinal centre B-cell (GCB) and non-GCB type of DLBCL based on immunohistochemistry. MYC translocation was observed in 9% (14 of 156), and an increased copy number (ICN) in 7.1% (11 of 156). MYC translocation was more common in GCB type (22%) than in non-GCB type (4.9%), and associated with advanced International Prognostic Index (IPI). MYC aberration, i.e. translocation or increased copy number (ICN), was significantly associated with shorter overall survival, especially for the GCB type. Bcl-2 translocation was rare (3.4%, five of 145), and ICN was observed in 11.7% (17 of 145), more frequently in non-GCB type (16%) than in GCB type (2.5%). Bcl-2 aberration tended to have an adverse effect on survival. In multivariate analysis, MYC ICN was an independent poor prognostic factor. CONCLUSIONS: Analyses of MYC and Bcl-2 status, i.e. translocation and ICN, in the context of DLBCL phenotype might help predict prognosis and determine therapeutic strategies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 205~217 | - |
dc.relation.isPartOf | HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | B-Lymphocytes/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Dosage* | - |
dc.subject.MESH | Germinal Center/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse/diagnosis* | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse/genetics* | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse/mortality | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-6/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/genetics* | - |
dc.subject.MESH | Translocation, Genetic* | - |
dc.title | MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | S O Yoon | - |
dc.contributor.googleauthor | Y K Jeon | - |
dc.contributor.googleauthor | J H Paik | - |
dc.contributor.googleauthor | W Y Kim | - |
dc.contributor.googleauthor | Y A Kim | - |
dc.contributor.googleauthor | J E Kim | - |
dc.contributor.googleauthor | C W Kim | - |
dc.identifier.doi | 10.1111/j.1365-2559.2008.03076.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02566 | - |
dc.relation.journalcode | J00994 | - |
dc.identifier.eissn | 1365-2559 | - |
dc.identifier.pmid | 18752503 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2559.2008.03076.x/abstract | - |
dc.subject.keyword | Bcl-2 | - |
dc.subject.keyword | Bcl-6 | - |
dc.subject.keyword | chromosome translocation | - |
dc.subject.keyword | diffuse large B cell lymphoma | - |
dc.subject.keyword | MYC | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 205 | - |
dc.citation.endPage | 217 | - |
dc.identifier.bibliographicCitation | HISTOPATHOLOGY, Vol.53(2) : 205-217, 2008 | - |
dc.identifier.rimsid | 37125 | - |
dc.type.rims | ART | - |
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