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Bioplex analysis of plasma cytokines in Alzheimer's disease and mild cognitive impairment

Authors
 Kang Soo Lee  ;  Ji Hyung Chung  ;  Kyung Hye Lee  ;  Min-Jeong Shin  ;  Byoung Hoon Oh  ;  Chang Hyung Hong 
Citation
 IMMUNOLOGY LETTERS, Vol.121(2) : 105-109, 2008 
Journal Title
 IMMUNOLOGY LETTERS 
ISSN
 0165-2478 
Issue Date
2008
MeSH
Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/diagnosis ; Alzheimer Disease/immunology* ; Alzheimer Disease/psychology ; Biomarkers/blood ; Chemokine CXCL9/blood* ; Chemokine CXCL9/genetics ; Chemokine CXCL9/immunology ; Cognition Disorders/blood ; Cognition Disorders/diagnosis ; Cognition Disorders/immunology* ; Cognition Disorders/psychology ; Cytokines/blood* ; Cytokines/genetics ; Cytokines/immunology ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Female ; Gene Expression Regulation/immunology ; Humans ; Intramolecular Oxidoreductases/blood* ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/immunology ; Macrophage Migration-Inhibitory Factors/blood* ; Macrophage Migration-Inhibitory Factors/genetics ; Macrophage Migration-Inhibitory Factors/immunology ; Male ; Polymers ; Prognosis
Keywords
Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/diagnosis ; Alzheimer Disease/immunology* ; Alzheimer Disease/psychology ; Biomarkers/blood ; Chemokine CXCL9/blood* ; Chemokine CXCL9/genetics ; Chemokine CXCL9/immunology ; Cognition Disorders/blood ; Cognition Disorders/diagnosis ; Cognition Disorders/immunology* ; Cognition Disorders/psychology ; Cytokines/blood* ; Cytokines/genetics ; Cytokines/immunology ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Female ; Gene Expression Regulation/immunology ; Humans ; Intramolecular Oxidoreductases/blood* ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/immunology ; Macrophage Migration-Inhibitory Factors/blood* ; Macrophage Migration-Inhibitory Factors/genetics ; Macrophage Migration-Inhibitory Factors/immunology ; Male ; Polymers ; Prognosis
Abstract
Inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Sixty-nine subjects were consecutively recruited from October 2005 to February 2007. Fifteen individuals were excluded from the study and we ultimately enrolled 19 not cognitively impaired subjects, 25 mild cognitive impairment patients, and 10 Alzheimer's disease patients. To examine the inflammatory markers of mild cognitive impairment and Alzheimer's disease, we measured the plasma concentrations of 23 cytokines using a bioplex assay. The results showed that the macrophage migration inhibitory factor was higher in mild cognitive impairment and in Alzheimer's disease patients compared with the not cognitively impaired group; the results also showed that monokine induced by gamma interferon was higher in Alzheimer's disease patients than in not cognitively impaired subjects, as well as those of the mild cognitive impairment group [corrected].
Full Text
http://www.sciencedirect.com/science/article/pii/S0165247808002186
DOI
10.1016/j.imlet.2008.09.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Byong Hoon(오병훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108522
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