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Transfusion-associated iron overload as an adverse risk factor for transplantation outcome in patients undergoing reduced-intensity stem cell transplantation for myeloid malignancies

DC Field Value Language
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author송재우-
dc.contributor.author정주원-
dc.date.accessioned2015-05-19T17:35:57Z-
dc.date.available2015-05-19T17:35:57Z-
dc.date.issued2008-
dc.identifier.issn0001-5792-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108453-
dc.description.abstractTransfusion-associated iron overload could be an important risk factor in myeloablative hematopoietic stem cell transplantation. However, few studies have evaluated the effect of iron overload in reduced-intensity stem cell transplantation (RIST). We evaluated 38 patients with myeloid malignancies, 16 with and 22 without iron overload, who received RIST. We used pretransplant serum ferritin as a marker of iron overload. There was a positive correlation between the number of transfused packed red blood cells and pretransplant serum ferritin levels (21.5 units and 1,578.7 microg/l in the iron overload group vs. 12 units and 739.3 microg/l in the iron non-overload group; p <0.01). Engraftment day and chimerism analysis were not affected by iron overload (p = 0.71 and 0.47, respectively). There were no differences in treatment-related mortality (p = 0.94), veno-occlusive disease (p = 0.99), acute and chronic graft versus host disease (p = 0.58 and 0.99, respectively) according to iron overload. There was a significant difference in disease-free and overall survival (35.8 and 27% in the iron overload group vs. 80.6 and 54.6% in the iron non-overload group; p = 0.01 and 0.03, respectively). We conclude that transfusion-associated iron overload is an adverse risk factor in RIST for myeloid malignancies. The clinical outcomes according to iron overload in RIST were different in myeloablative hematopoietic stem cell transplantation. A serial follow-up of serum ferritin level and judicious iron chelation therapy will be needed to manage the side effect of iron overload in RIST and improve transplantation outcomes-
dc.description.statementOfResponsibilityopen-
dc.format.extent182~189-
dc.relation.isPartOfACTA HAEMATOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHErythrocyte Transfusion*-
dc.subject.MESHFemale-
dc.subject.MESHFerritins/blood*-
dc.subject.MESHHematologic Neoplasms/blood*-
dc.subject.MESHHematologic Neoplasms/mortality-
dc.subject.MESHHematologic Neoplasms/therapy*-
dc.subject.MESHHematopoietic Stem Cell Transplantation*-
dc.subject.MESHHumans-
dc.subject.MESHIron Chelating Agents/therapeutic use-
dc.subject.MESHIron Overload/blood*-
dc.subject.MESHIron Overload/drug therapy-
dc.subject.MESHIron Overload/etiology-
dc.subject.MESHIron Overload/mortality-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRisk Factors-
dc.titleTransfusion-associated iron overload as an adverse risk factor for transplantation outcome in patients undergoing reduced-intensity stem cell transplantation for myeloid malignancies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKim YR-
dc.contributor.googleauthorKim JS-
dc.contributor.googleauthorCheong JW-
dc.contributor.googleauthorSong JW-
dc.contributor.googleauthorMin YH-
dc.identifier.doi10.1159/000187646-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA02054-
dc.contributor.localIdA03726-
dc.relation.journalcodeJ00014-
dc.identifier.eissn1421-9662-
dc.identifier.pmid19129689-
dc.identifier.urlhttp://www.karger.com/Article/FullText/187646-
dc.subject.keywordIron overload-
dc.subject.keywordTransfusion-
dc.subject.keywordReduced-intensity stem cell transplantation-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.alternativeNameChung, Joo Won-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.contributor.affiliatedAuthorChung, Joo Won-
dc.rights.accessRightsnot free-
dc.citation.volume120-
dc.citation.number3-
dc.citation.startPage182-
dc.citation.endPage189-
dc.identifier.bibliographicCitationACTA HAEMATOLOGICA, Vol.120(3) : 182-189, 2008-
dc.identifier.rimsid35586-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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