Cited 106 times in

Fucoidan inhibits UVB-induced MMP-1 expression in human skin fibroblasts

Authors
 Hee Jung MOON  ;  Soon Rye LEE  ;  Sun Nyu SHIM  ;  Seok Hoon JEONG  ;  Valentine A. STONIK  ;  Valery A. RASSKAZOV  ;  Tatyana ZVYAGINTSEVA  ;  Yong Hwan LEE 
Citation
 BIOLOGICAL & PHARMACEUTICAL BULLETIN, Vol.31(2) : 284-289, 2008 
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN
 0918-6158 
Issue Date
2008
Keywords
matrix metalloproteinase-1 ; fucoidan ; ultraviolet B
Abstract
Ultraviolet (UV)B irradiation induces the production of matrix metalloproteinases (MMPs) by activating cellular signaling transduction pathways, which are responsible for the degradation or synthesis inhibition of collagenous extracellular matrix in connective tissues, causing skin photoaging. Using the human skin fibroblast (HS68) cell line in the present study, we investigated the inhibitory effects of fucoidan on MMP-1 expression by various in vitro experiments and elucidated the pathways of inhibition. Pretreatment with fucoidan inhibited UVB-induced MMP-1 expression in a dose-dependent manner. Extracellular signal regulated kinase (ERK) activation was markedly inhibited by treatment with fucoidan, though JNK activation was very slightly affected by fucoidan. We also found that fucoidan pretreatment significantly reduced MMP-1 mRNA expression in comparison with UVB irradiation only. In conclusion, our results demonstrate that fucoidan can mainly inhibit UVB-induced MMP-1 expression by inhibiting the ERK pathways. Therefore, fucoidan might be used as a potential agent for the prevention and treatment of skin photoaging
Files in This Item:
T200805596.pdf Download
DOI
10.1248/bpb.31.284
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108414
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links