Cited 34 times in
The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 심연희 | - |
dc.date.accessioned | 2015-05-19T17:32:51Z | - |
dc.date.available | 2015-05-19T17:32:51Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0003-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108351 | - |
dc.description.abstract | BACKGROUND: Helium produces preconditioning against myocardial infarction by activating prosurvival signaling, but whether nitric oxide (NO) generated by endothelial NO synthase plays a role in this phenomenon is unknown. We tested the hypothesis that NO mediates helium-induced cardioprotection in vivo. METHODS: Rabbits (n = 62) instrumented for hemodynamic measurement were subjected to a 30-min left anterior descending coronary artery occlusion and 3 h reperfusion, and received 0.9% saline (control) or three cycles of 70% helium-30% oxygen administered for 5 min interspersed with 5 min of an air-oxygen mixture before left anterior descending coronary artery occlusion in the absence or presence of pretreatment with the nonselective NOS inhibitor N-nitro-l-arginine methyl ester (L-NAME; 10 mg/kg), the selective inducible NOS inhibitor aminoguanidine hydrochloride (AG; 300 mg/kg), or selective neuronal NOS inhibitor 7-nitroindazole (7-NI; 50 mg/kg). In additional rabbits, the fluorescent probe 4,5-diaminofluroscein diacetate (DAF-2DA) and confocal laser microscopy were used to detect NO production in the absence or presence of helium with or without L-NAME pretreatment. RESULTS: Helium reduced (P < 0.05) infarct size (24% +/- 4% of the left ventricular area at risk; mean +/- sd) compared with control (46% +/- 3%). L-NAME, AG, and 7-NI did not alter myocardial infarct size when administered alone. L-NAME, but not 7-NI or AG, abolished helium-induced cardioprotection. Helium enhanced DAF-2DA fluorescence compared with control (26 +/- 8 vs 15 +/- 5 U, respectively). Pretreatment with L-NAME abolished these helium-induced increases in DAF-2DA fluorescence. CONCLUSIONS: The results indicate that cardioprotection by helium is mediated by NO that is probably generated by endothelial NOS in vivo | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 762~768 | - |
dc.relation.isPartOf | ANESTHESIA AND ANALGESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cardiotonic Agents/pharmacology* | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Fluorescein/pharmacology | - |
dc.subject.MESH | Helium/pharmacology* | - |
dc.subject.MESH | Hemodynamics | - |
dc.subject.MESH | Indazoles/pharmacology | - |
dc.subject.MESH | Indicators and Reagents/pharmacology | - |
dc.subject.MESH | Ischemic Preconditioning, Myocardial* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopy, Confocal/methods | - |
dc.subject.MESH | NG-Nitroarginine Methyl Ester/pharmacology | - |
dc.subject.MESH | Nitric Oxide/metabolism* | - |
dc.subject.MESH | Nitric Oxide Synthase Type III/metabolism* | - |
dc.subject.MESH | Rabbits | - |
dc.title | The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Paul S. Pagel | - |
dc.contributor.googleauthor | John G. Krolikowski | - |
dc.contributor.googleauthor | Phillip F. Pratt Jr | - |
dc.contributor.googleauthor | Yon Hee Shim | - |
dc.contributor.googleauthor | Julien Amour | - |
dc.contributor.googleauthor | David C. Warltier | - |
dc.contributor.googleauthor | Dorothee Weihrauch | - |
dc.identifier.doi | 10.1213/ane.0b013e3181815995 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02196 | - |
dc.relation.journalcode | J00144 | - |
dc.identifier.eissn | 1526-7598 | - |
dc.identifier.pmid | 18713880 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Cardiotonic Agents/pharmacology* | - |
dc.subject.keyword | Enzyme Inhibitors/pharmacology | - |
dc.subject.keyword | Fluorescein/pharmacology | - |
dc.subject.keyword | Helium/pharmacology* | - |
dc.subject.keyword | Hemodynamics | - |
dc.subject.keyword | Indazoles/pharmacology | - |
dc.subject.keyword | Indicators and Reagents/pharmacology | - |
dc.subject.keyword | Ischemic Preconditioning, Myocardial* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Microscopy, Confocal/methods | - |
dc.subject.keyword | NG-Nitroarginine Methyl Ester/pharmacology | - |
dc.subject.keyword | Nitric Oxide/metabolism* | - |
dc.subject.keyword | Nitric Oxide Synthase Type III/metabolism* | - |
dc.subject.keyword | Rabbits | - |
dc.contributor.alternativeName | Shim, Yon Hee | - |
dc.contributor.affiliatedAuthor | Shim, Yon Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 107 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 762 | - |
dc.citation.endPage | 768 | - |
dc.identifier.bibliographicCitation | ANESTHESIA AND ANALGESIA, Vol.107(3) : 762-768, 2008 | - |
dc.identifier.rimsid | 35507 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.