Cited 32 times in
Reactive Oxygen Species and Mitochondrial Adenosine Triphosphate-Regulated Potassium Channels Mediate Helium-Induced Preconditioning Against Myocardial Infarction In Vivo
DC Field | Value | Language |
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dc.contributor.author | 심연희 | - |
dc.date.accessioned | 2015-05-19T17:32:49Z | - |
dc.date.available | 2015-05-19T17:32:49Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1053-0770 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108350 | - |
dc.description.abstract | OBJECTIVES: Helium produces preconditioning by activating prosurvival kinases, but the roles of reactive oxygen species (ROS) or mitochondrial adenosine triphosphate-regulated potassium (K(ATP)) channels in this process are unknown. The authors tested the hypothesis that ROS and mitochondrial K(ATP) channels mediate helium-induced preconditioning in vivo. DESIGN: A randomized, prospective study. SETTING: A university research laboratory. PARTICIPANTS: Male New Zealand white rabbits. INTERVENTIONS: Rabbits (n = 64) were instrumented for the measurement of systemic hemodynamics and subjected to a 30-minute left anterior descending coronary artery (LAD) occlusion and 3 hours of reperfusion. In separate experimental groups, rabbits (n = 7 or 8 per group) were randomly assigned to receive 0.9% saline (control) or 3 cycles of 70% helium-30% oxygen administered for 5 minutes interspersed with 5 minutes of an air-oxygen mixture before LAD occlusion with or without the ROS scavengers N-acetylcysteine (NAC; 150 mg/kg) or N-2 mercaptoproprionyl glycine (2-MPG; 75 mg/kg), or the mitochondrial K(ATP) antagonist 5-hydroxydecanoate (5-HD; 5 mg/kg). Statistical analysis of data was performed with analysis of variance for repeated measures followed by Bonferroni's modification of a Student t test. MEASUREMENTS AND MAIN RESULTS: The myocardial infarct size was determined by using triphenyltetrazolium chloride staining and presented as a percentage of the left ventricular area at risk. Helium significantly (p < 0.05) reduced infarct size (23 +/- 4% of the area at risk; mean +/- standard deviation) compared with control (46 +/- 3%). NAC, 2-MPG, and 5-HD did not affect irreversible ischemic injury when administered alone (49 +/- 5%, 45 +/- 6%, and 45 +/- 3%), but these drugs blocked reductions in infarct size produced by helium (45 +/- 4%, 45 +/- 2%, and 44 +/- 3%). CONCLUSIONS: The results suggest that ROS and mitochondrial K(ATP) channels mediate helium-induced preconditioning in vivo. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 554~559 | - |
dc.relation.isPartOf | JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenosine Triphosphate/physiology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Helium/pharmacology | - |
dc.subject.MESH | Helium/therapeutic use* | - |
dc.subject.MESH | Ischemic Preconditioning, Myocardial/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mitochondria, Heart/drug effects | - |
dc.subject.MESH | Mitochondria, Heart/physiology | - |
dc.subject.MESH | Myocardial Infarction/metabolism | - |
dc.subject.MESH | Myocardial Infarction/prevention & control* | - |
dc.subject.MESH | Potassium Channels/physiology* | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.title | Reactive Oxygen Species and Mitochondrial Adenosine Triphosphate-Regulated Potassium Channels Mediate Helium-Induced Preconditioning Against Myocardial Infarction In Vivo | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Paul S. Pagel | - |
dc.contributor.googleauthor | John G. Krolikowski | - |
dc.contributor.googleauthor | Phillip F. Pratt Jr | - |
dc.contributor.googleauthor | Yon Hee Shim | - |
dc.contributor.googleauthor | Julien Amour | - |
dc.contributor.googleauthor | David C. Warltier | - |
dc.contributor.googleauthor | Dorothee Weihrauch | - |
dc.identifier.doi | 10.1053/j.jvca.2008.04.005 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02196 | - |
dc.relation.journalcode | J01289 | - |
dc.identifier.eissn | 1532-8422 | - |
dc.identifier.pmid | 18662630 | - |
dc.subject.keyword | myocardial ischemia | - |
dc.subject.keyword | preconditioning | - |
dc.subject.keyword | helium | - |
dc.subject.keyword | reactive oxygen species | - |
dc.subject.keyword | mitochondrial adenosine triphosphate–regulated potassium channels | - |
dc.contributor.alternativeName | Shim, Yon Hee | - |
dc.contributor.affiliatedAuthor | Shim, Yon Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 554 | - |
dc.citation.endPage | 559 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, Vol.22(4) : 554-559, 2008 | - |
dc.identifier.rimsid | 35506 | - |
dc.type.rims | ART | - |
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