Cited 36 times in
Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동욱 | - |
dc.date.accessioned | 2015-05-19T17:30:11Z | - |
dc.date.available | 2015-05-19T17:30:11Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108268 | - |
dc.description.abstract | Recently, Bmi1 was shown to control the proliferation and self-renewal of neural stem cells (NSCs). In this study, we demonstrated the induction of NSC-like cells (NSCLCs) from mouse astrocytes by Bmi1 under NSC culture conditions. These NSCLCs exhibited the morphology and growth properties of NSCs, and expressed NSC marker genes, including nestin, CD133, and Sox2. In vitro differentiation of NSCLCs resulted in differentiated cell populations containing astrocytes, neurons, and oligodendrocytes. Following treatment with histone deacetylase inhibitors (trichostatin A and valproic acid), the potential of NSCLCs for proliferation, dedifferentiation, and self-renewal was significantly inhibited. Our data indicate that multipotent NSCLCs can be generated directly from astrocytes by the addition of Bmi1. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 267~272 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | AC133 Antigen | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, CD/genetics | - |
dc.subject.MESH | Astrocytes/cytology | - |
dc.subject.MESH | Astrocytes/drug effects | - |
dc.subject.MESH | Astrocytes/metabolism | - |
dc.subject.MESH | Cell Culture Techniques | - |
dc.subject.MESH | Cell Differentiation*/genetics | - |
dc.subject.MESH | Cell Lineage/genetics | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p16/metabolism | - |
dc.subject.MESH | DNA-Binding Proteins/genetics | - |
dc.subject.MESH | Genetic Markers | - |
dc.subject.MESH | Glycoproteins/genetics | - |
dc.subject.MESH | HMGB Proteins/genetics | - |
dc.subject.MESH | Intermediate Filament Proteins/genetics | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Multipotent Stem Cells/cytology* | - |
dc.subject.MESH | Multipotent Stem Cells/metabolism | - |
dc.subject.MESH | Nerve Tissue Proteins/genetics | - |
dc.subject.MESH | Nestin | - |
dc.subject.MESH | Neurons/cytology* | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Nuclear Proteins/genetics | - |
dc.subject.MESH | Nuclear Proteins/physiology* | - |
dc.subject.MESH | Peptides/genetics | - |
dc.subject.MESH | Polycomb Repressive Complex 1 | - |
dc.subject.MESH | Protein Kinase Inhibitors/pharmacology | - |
dc.subject.MESH | Proto-Oncogene Proteins/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins/physiology* | - |
dc.subject.MESH | Repressor Proteins/genetics | - |
dc.subject.MESH | Repressor Proteins/physiology* | - |
dc.subject.MESH | SOXB1 Transcription Factors | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.title | Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Jai-Hee Moon | - |
dc.contributor.googleauthor | Byung Sun Yoon | - |
dc.contributor.googleauthor | Bona Kim | - |
dc.contributor.googleauthor | Gyuman Park | - |
dc.contributor.googleauthor | Hye-Youn Jung | - |
dc.contributor.googleauthor | Isaac Maeng | - |
dc.contributor.googleauthor | Eun Kyoung Jun | - |
dc.contributor.googleauthor | Seung Jun Yoo | - |
dc.contributor.googleauthor | Aeree Kim | - |
dc.contributor.googleauthor | Sejong Oh | - |
dc.contributor.googleauthor | Kwang Youn Whang | - |
dc.contributor.googleauthor | Hyunggee Kim | - |
dc.contributor.googleauthor | Dong-Wook Kim | - |
dc.contributor.googleauthor | Ki Dong Kim | - |
dc.contributor.googleauthor | Seungkwon You | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.04.068 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00406 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 18439910 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X08007262 | - |
dc.subject.keyword | Neural stem cells | - |
dc.subject.keyword | Astrocytes | - |
dc.subject.keyword | Dedifferentiation | - |
dc.subject.keyword | Neural stem cell-like cells | - |
dc.contributor.alternativeName | Kim, Dong Wook | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 371 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 267 | - |
dc.citation.endPage | 272 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.371(2) : 267-272, 2008 | - |
dc.identifier.rimsid | 35296 | - |
dc.type.rims | ART | - |
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