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정신분열병 환자의 인슐린저항성 결정인자

DC FieldValueLanguage
dc.contributor.author남지선-
dc.contributor.author박종숙-
dc.contributor.author안철우-
dc.contributor.author조민호-
dc.contributor.author김경래-
dc.contributor.author김찬형-
dc.contributor.author남윤영-
dc.date.accessioned2015-05-19T17:30:07Z-
dc.date.available2015-05-19T17:30:07Z-
dc.date.issued2008-
dc.identifier.issn1738-9364-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108266-
dc.description.abstractBackground/Aims: As compared with the general population, patients with schizophrenia have a higher risk of obesity and glucose metabolism impairment. Moreover, some antipsychotic drugs add to this risk owing to side effects such as weight gain. However, few reports exist regarding the pathophysiology of insulin resistance in drug-naive or drug-free schizophrenic patients. Therefore, the aim of the present study was to investigate the factors that contribute to insulin resistance in antipsychotic drug-naive and drug-free schizophrenic patients. Methods: Nineteen (4 men, 15 women) drug-naive or drug-free subjects with schizophrenia and nineteen age- and sex-matched controls were recruited for participation in this study. We measured weight, height, waist circumference, biochemical profiles, body fat percentage, and calculated body mass indices (BMI) in all patients. Furthermore, we correlated HOMA-IR, a marker for insulin resistance, with anthropometric measures and clinical characteristics. Results: There were no significant differences in BMI, waist circumference, or body fat percentage between the two groups. In addition, there were no differences in blood pressure, glucose, HbA1c, insulin, HOMA-IR, total cholesterol, HDL-cholesterol, or LDL-cholesterol; however, triglyceride levels and 24 hr urine free cortisol levels were higher in schizophrenic patients. There was also a significant correlation between HOMA-IR and both age and waist circumference in the control group. Additionally, HOMA-IR was significantly correlated with 24 hr urine free cortisol levels in schizophrenic patients. Conclusions: The study shows that risk factors for insulin resistance in drug-naive or drug-free schizophrenic patients do not differ from those of the control group; however, the major determinant of insulin resistance in schizophrenia patients was that of increased cortisol levels-
dc.description.statementOfResponsibilityopen-
dc.format.extent673~679-
dc.relation.isPartOfKorean Journal of Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title정신분열병 환자의 인슐린저항성 결정인자-
dc.title.alternativeA determinant of insulin resistance in patients with schizophrenia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthor김철식-
dc.contributor.googleauthor조민호-
dc.contributor.googleauthor남지선-
dc.contributor.googleauthor박종숙-
dc.contributor.googleauthor남윤영-
dc.contributor.googleauthor김찬형-
dc.contributor.googleauthor안철우-
dc.contributor.googleauthor김경래-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01268-
dc.contributor.localIdA02270-
dc.contributor.localIdA03819-
dc.contributor.localIdA00294-
dc.contributor.localIdA01036-
dc.contributor.localIdA01261-
dc.contributor.localIdA01660-
dc.relation.journalcodeJ02059-
dc.identifier.pmidSchizophrenia; Diabetes Mellitus; Insulin Resistance-
dc.subject.keywordSchizophrenia-
dc.subject.keywordDiabetes Mellitus-
dc.subject.keywordInsulin Resistance-
dc.contributor.alternativeNameNam, Ji Sun-
dc.contributor.alternativeNamePark, Jong Suk-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameCho, Min Ho-
dc.contributor.alternativeNameKim, Kyung Rae-
dc.contributor.alternativeNameKim, Chan Hyung-
dc.contributor.alternativeNameNam, Yoon Young-
dc.contributor.affiliatedAuthorNam, Ji Sun-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorCho, Min Ho-
dc.contributor.affiliatedAuthorKim, Kyung Rae-
dc.contributor.affiliatedAuthorKim, Chan Hyung-
dc.contributor.affiliatedAuthorNam, Yoon Young-
dc.contributor.affiliatedAuthorPark, Jong Suk-
dc.rights.accessRightsfree-
dc.citation.volume75-
dc.citation.number6-
dc.citation.startPage673-
dc.citation.endPage679-
dc.identifier.bibliographicCitationKorean Journal of Medicine, Vol.75(6) : 673-679, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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