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Hollow silica nanocontainers as drug delivery vehicles.

Authors
 Jaemoon Yang  ;  Jaewon Lee  ;  Jinyoung Kang  ;  Kwangyeol Lee  ;  Jin-Suck Suh  ;  Ho-Geun Yoon  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 LANGMUIR, Vol.24(7) : 3417-3421, 2008 
Journal Title
 LANGMUIR 
ISSN
 0743-7463 
Issue Date
2008
MeSH
Doxorubicin/administration & dosage ; Drug Delivery Systems ; Ferric Compounds ; Nanocapsules/chemistry* ; Silicon Dioxide* ; Structure-Activity Relationship
Keywords
Doxorubicin/administration & dosage ; Drug Delivery Systems ; Ferric Compounds ; Nanocapsules/chemistry* ; Silicon Dioxide* ; Structure-Activity Relationship
Abstract
Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
Full Text
http://pubs.acs.org/doi/abs/10.1021/la701688t
DOI
10.1021/la701688t
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108212
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