Hollow silica nanocontainers as drug delivery vehicles.

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Authors: Jaemoon Yang ; Jaewon Lee ; Jinyoung Kang ; Kwangyeol Lee ; Jin-Suck Suh ; Ho-Geun Yoon ; Yong-Min Huh ; Seungjoo Haam

MeSH: Doxorubicin/administration & dosage ; Drug Delivery Systems ; Ferric Compounds ; Nanocapsules/chemistry* ; Silicon Dioxide* ; Structure-Activity Relationship

Keywords: Doxorubicin/administration & dosage ; Drug Delivery Systems ; Ferric Compounds ; Nanocapsules/chemistry* ; Silicon Dioxide* ; Structure-Activity Relationship

Abstract: Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

Yonsei Authors: Suh, Jin Suck(서진석) https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) https://orcid.org/0000-0002-9831-4475

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