Cited 54 times in
Histological and biomechanical properties of regenerated articular cartilage using chondrogenic bone marrow stromal cells with a PLGA scaffold in vivo
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.contributor.author | 이진우 | - |
dc.date.accessioned | 2015-05-19T17:27:55Z | - |
dc.date.available | 2015-05-19T17:27:55Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108198 | - |
dc.description.abstract | The properties of regenerated cartilage using bone marrow-derived mesenchymal stem cells (MSCs) and poly lactic-co-glycolic acid (PLGA) scaffold composites pretreated with TGF-beta3 were investigated and compared to the non-TGF-beta3 treated MSCs/PLGA composites in a rabbit model. We prepared MSCs/PLGA scaffold composites and pretreated it with TGF-beta3 for 3 weeks prior to transplantation. Then, composites were transplanted to the osteochondral defect in the rabbit knee. After 12 weeks of transplantation, 10 of the 12 rabbits in which TGF-beta3 pretreated MSCs/PLGA scaffold composites were transplanted showed cartilaginous regeneration. In gross morphology, regenerated cartilage showed smooth, flush, and transparent features. In indentation test, this had about 80% of Young's modulus of normal articular cartilage. Histological examination demonstrated hyaline like cartilage structures with glycosaminoglycan and type II collagen expression. Histological scores were not statistically different to the normal articular cartilage. These results showed improvement of cartilage regeneration compared to the non-TGF-beta3 pretreated MSCs/PLGA scaffold composite transplanted group. Thus, we have successfully regenerated improved hyaline-like cartilage and determined the feasibility of treating damaged articular cartilage using MSCs/PLGA scaffold composite pretreated with TGF-beta3. Also, we suggest this treatment modality as another concept of cartilage tissue engineering. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 850~861 | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biocompatible Materials/chemistry | - |
dc.subject.MESH | Biomechanical Phenomena | - |
dc.subject.MESH | Bone Marrow Cells/chemistry | - |
dc.subject.MESH | Bone Marrow Cells/cytology* | - |
dc.subject.MESH | Bone Marrow Cells/metabolism | - |
dc.subject.MESH | Cartilage, Articular*/cytology | - |
dc.subject.MESH | Cartilage, Articular*/pathology | - |
dc.subject.MESH | Cartilage, Articular*/physiology | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chondrogenesis/physiology | - |
dc.subject.MESH | Collagen/metabolism | - |
dc.subject.MESH | Glycosaminoglycans/metabolism | - |
dc.subject.MESH | Guided Tissue Regeneration/methods | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Knee Joint/pathology | - |
dc.subject.MESH | Knee Joint/physiology | - |
dc.subject.MESH | Lactic Acid/chemistry* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Materials Testing | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation/methods | - |
dc.subject.MESH | Mesenchymal Stem Cells/chemistry | - |
dc.subject.MESH | Mesenchymal Stem Cells/cytology* | - |
dc.subject.MESH | Mesenchymal Stem Cells/metabolism | - |
dc.subject.MESH | Polyglycolic Acid/chemistry* | - |
dc.subject.MESH | Polylactic Acid-Polyglycolic Acid Copolymer | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Stromal Cells/chemistry | - |
dc.subject.MESH | Stromal Cells/cytology* | - |
dc.subject.MESH | Stromal Cells/metabolism | - |
dc.subject.MESH | Tissue Engineering/methods* | - |
dc.subject.MESH | Tissue Scaffolds/chemistry* | - |
dc.title | Histological and biomechanical properties of regenerated articular cartilage using chondrogenic bone marrow stromal cells with a PLGA scaffold in vivo | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Seung Hwan Han | - |
dc.contributor.googleauthor | Yun Hee Kim | - |
dc.contributor.googleauthor | Min Sung Park | - |
dc.contributor.googleauthor | In Ae Kim | - |
dc.contributor.googleauthor | Jung Woog Shin | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Kyoung Soo Jee | - |
dc.contributor.googleauthor | Ki Dong Park | - |
dc.contributor.googleauthor | Gyu Ha Ryu | - |
dc.contributor.googleauthor | Jin Woo Lee | - |
dc.identifier.doi | 10.1002/jbm.a.31828 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03230 | - |
dc.relation.journalcode | J01266 | - |
dc.identifier.eissn | 1552-4965 | - |
dc.identifier.pmid | 18200543 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.31828/abstract | - |
dc.subject.keyword | bone marrow-derived mesenchymal stem cells | - |
dc.subject.keyword | poly lactic-co-glycolic acid | - |
dc.subject.keyword | cartilage | - |
dc.subject.keyword | cartilage tissue engi-neering | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Lee, Jin Woo | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Lee, Jin Woo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 87 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 850 | - |
dc.citation.endPage | 861 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.87(4) : 850-861, 2008 | - |
dc.identifier.rimsid | 35245 | - |
dc.type.rims | ART | - |
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