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Cited 8 times in

Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors

DC FieldValueLanguage
dc.contributor.author김재욱-
dc.contributor.author김재훈-
dc.contributor.author남은지-
dc.contributor.author윤보성-
dc.contributor.author조남훈-
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.date.accessioned2015-05-19T17:27:21Z-
dc.date.available2015-05-19T17:27:21Z-
dc.date.issued2008-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108181-
dc.description.abstractPURPOSE: We evaluated the expression of microsatellite instability (MSI) in sporadic ovarian tumors using 5 standard and 9 new MSI markers to determine the clinical significance of MSI in sporadic epithelial ovarian tumors. MATERIALS AND METHODS: MSI was examined in 21 borderline and 25 malignant ovarian tumors. Polymerase chain reaction (PCR) was performed using the 5 markers recommended by the National Cancer Institute (NCI) for colon cancer and 9 additional markers. MSI was determined using fractional analysis by mixing the PCR products and size markers. RESULTS: Using the 5 conventional MSI markers, MSI was found in 4 of 46 (8.6%) ovarian tumors, including 2 of 21 (9.5%) borderline ovarian tumors and 2 of 25 (8%) malignant ovarian tumors. Using the 9 additional MSI markers, MSI was observed in 7 of 46 (15.2%) ovarian tumors, including 3 of 21 (14.3%) borderline ovarian tumors and 4 of 25 (16%) malignant ovarian tumors. There was no statistically significant difference between MSI and clinicopathological factors, including histology and stage, although there was a trend toward an increased incidence of MSI in the serous type. CONCLUSION: MSI was infrequent in ovarian tumors, including both borderline and malignant tumors. MSI was found to be uncommon in sporadic ovarian tumors, even by using additional MSI markers. The clinical significance of MSI is not strong in patients with sporadic ovarian tumors.-
dc.description.statementOfResponsibilityopen-
dc.format.extent272~278-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHDNA, Neoplasm/genetics-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMicrosatellite Instability*-
dc.subject.MESHOvarian Neoplasms/genetics*-
dc.subject.MESHOvarian Neoplasms/pathology*-
dc.subject.MESHPolymerase Chain Reaction-
dc.titleClinical significance of microsatellite instability in sporadic epithelial ovarian tumors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorBo-Sung Yoon-
dc.contributor.googleauthorYoung-Tae Kim-
dc.contributor.googleauthorJae-Hoon Kim-
dc.contributor.googleauthorSang-Wun Kim-
dc.contributor.googleauthorEun-Ji Nam-
dc.contributor.googleauthorNam-Hoon Cho-
dc.contributor.googleauthorJae-Wook Kim-
dc.contributor.googleauthorSunghoon Kim-
dc.identifier.doi10.3349/ymj.2008.49.2.272-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00595-
dc.contributor.localIdA00866-
dc.contributor.localIdA00876-
dc.contributor.localIdA01262-
dc.contributor.localIdA02554-
dc.contributor.localIdA03812-
dc.contributor.localIdA00526-
dc.contributor.localIdA00729-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid18452265-
dc.subject.keywordMicrosatellite instability-
dc.subject.keywordpolymerase chain reaction-
dc.subject.keywordovarian neoplasms-
dc.contributor.alternativeNameKim, Jae Wook-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.alternativeNameNam, Eun Ji-
dc.contributor.alternativeNameYoon, Bo Sung-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Jae Wook-
dc.contributor.affiliatedAuthorKim, Jae Hoon-
dc.contributor.affiliatedAuthorNam, Eun Ji-
dc.contributor.affiliatedAuthorYoon, Bo Sung-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.rights.accessRightsfree-
dc.citation.volume49-
dc.citation.number2-
dc.citation.startPage272-
dc.citation.endPage278-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.49(2) : 272-278, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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