268 602

Cited 52 times in

Pancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study

DC Field Value Language
dc.contributor.author윤지은-
dc.contributor.author지선하-
dc.date.accessioned2015-05-19T17:25:42Z-
dc.date.available2015-05-19T17:25:42Z-
dc.date.issued2008-
dc.identifier.issn1055-9965-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108128-
dc.description.abstractThere is increasing evidence that type 2 diabetes mellitus and glucose intolerance are a cause, not just a consequence, of pancreatic cancer. We examined whether other factors that characterize the insulin resistance syndrome are also risk factors for pancreatic cancer in a prospective cohort study of 631,172 men and women (ages 45+ years) who received health insurance from the Korean Medical Insurance Corporation. The biennial medical evaluations from 1992 to 1995 provided the baseline information for this study. Relative risks (RR) were estimated using proportional hazards models adjusted for age, sex, smoking, and fasting serum glucose (after excluding the first 2 years of follow-up). There were 2,194 incident cases of pancreatic cancer diagnosed in the cohort over a median follow-up of 12 years. There was no evidence that pancreatic cancer risk was associated with total cholesterol, systolic blood pressure, WBC count, or body mass index. Abnormal levels of aspartate aminotransferase and alanine aminotransferase were both associated with a moderately increased risk of developing the disease (40+ versus <20; RR, 1.33; 95% CI, 1.14-1.55; P(trend) = 0.05 and RR, 1.34; 95% CI, 1.16-1.56; P(trend) = 0.02, respectively). Excluding 6 years of follow-up reduced this RR (95% CI) for aspartate aminotransferase to 1.22 (1.01-1.49), but even after excluding 10 years follow-up the RR (95% CI) for alanine aminotransferase was unchanged [1.36 (1.01-1.83)]. Although fasting serum glucose has been found previously to be associated with pancreatic cancer risk in this cohort, most other factors that characterize insulin resistance syndrome were not associated with pancreatic cancer risk. The association with elevated liver enzyme levels is a novel finding that warrants further investigation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent359~364-
dc.relation.isPartOfCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlanine Transaminase/metabolism-
dc.subject.MESHAspartate Aminotransferases/metabolism-
dc.subject.MESHBody Mass Index-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance*-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHLipids/blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPancreatic Neoplasms/epidemiology-
dc.subject.MESHPancreatic Neoplasms/etiology*-
dc.subject.MESHPancreatic Neoplasms/prevention & control*-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSmoking/adverse effects-
dc.subject.MESHSmoking/epidemiology-
dc.titlePancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorAmy Berrington de Gonzalez-
dc.contributor.googleauthorJi Eun Yun-
dc.contributor.googleauthorSang-Yi Lee-
dc.contributor.googleauthorAlison P. Klein-
dc.contributor.googleauthorSun Ha Jee-
dc.identifier.doi10.1158/1055-9965.EPI-07-0507-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02608-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00441-
dc.identifier.eissn1538-7755-
dc.identifier.pmid18268120-
dc.subject.keywordAlanine Transaminase/metabolism-
dc.subject.keywordAspartate Aminotransferases/metabolism-
dc.subject.keywordBody Mass Index-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordInsulin Resistance*-
dc.subject.keywordKorea/epidemiology-
dc.subject.keywordLipids/blood-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordPancreatic Neoplasms/epidemiology-
dc.subject.keywordPancreatic Neoplasms/etiology*-
dc.subject.keywordPancreatic Neoplasms/prevention & control*-
dc.subject.keywordProportional Hazards Models-
dc.subject.keywordProspective Studies-
dc.subject.keywordRisk Factors-
dc.subject.keywordSmoking/adverse effects-
dc.subject.keywordSmoking/epidemiology-
dc.contributor.alternativeNameYun, Ji Eun-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorYun, Ji Eun-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsfree-
dc.citation.volume17-
dc.citation.number2-
dc.citation.startPage359-
dc.citation.endPage364-
dc.identifier.bibliographicCitationCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol.17(2) : 359-364, 2008-
dc.identifier.rimsid35201-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.