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The effect of bolus administration of remifentanil on QTc interval during induction of sevoflurane anaesthesia

Authors
 T. D. Kweon  ;  S. B. Nam  ;  C. H. Chang  ;  M. S. Kim  ;  J. S. Lee  ;  C. S. Shin  ;  D. B. June  ;  D. W. Han 
Citation
 ANAESTHESIA, Vol.63(4) : 347-351, 2008 
Journal Title
 ANAESTHESIA 
ISSN
 0003-2409 
Issue Date
2008
MeSH
Adult ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use* ; Anesthetics, Inhalation* ; Blood Pressure/drug effects ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Heart Rate/drug effects ; Humans ; Intubation, Intratracheal/adverse effects ; Laryngoscopy/adverse effects ; Long QT Syndrome/etiology ; Long QT Syndrome/prevention & control* ; Male ; Methyl Ethers* ; Middle Aged ; Piperidines/administration & dosage* ; Piperidines/adverse effects ; Remifentanil ; Sevoflurane
Keywords
Adult ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use* ; Anesthetics, Inhalation* ; Blood Pressure/drug effects ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Heart Rate/drug effects ; Humans ; Intubation, Intratracheal/adverse effects ; Laryngoscopy/adverse effects ; Long QT Syndrome/etiology ; Long QT Syndrome/prevention & control* ; Male ; Methyl Ethers* ; Middle Aged ; Piperidines/administration & dosage* ; Piperidines/adverse effects ; Remifentanil ; Sevoflurane
Abstract
Stimulation of the sympathetic nervous system associated with tracheal intubation causes corrected QT (QTc) interval prolongation. We postulated that the use of remifentanil during induction of anaesthesia might prevent this. Sixty unpremedicated, ASA grade 1 patients were selected and randomly allocated to receive either saline (group S), remifentanil 0.5 microg x kg(-1) (group R 0.5) or remifentanil 1.0 microg x kg(-1) (group R1.0) 1 min before laryngoscopy. The QTc interval was significantly prolonged immediately following intubation in group S and group R0.5, but it remained stable in group R1.0, compared with the QTc interval just before laryngoscopy. It is concluded that the administration of remifentanil 1.0 microg x kg(-1) before intubation can prevent the prolongation of the QTc interval associated with tracheal intubation during induction of anaesthesia with sevoflurane
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2007.05372.x/abstract
DOI
10.1111/j.1365-2044.2007.05372.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Nam, Sang Beom(남상범) ORCID logo https://orcid.org/0000-0002-9704-1866
Shin, Cheung Soo(신증수) ORCID logo https://orcid.org/0000-0001-7829-8458
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
Chang, Chul Ho(장철호) ORCID logo https://orcid.org/0000-0001-5647-8298
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108115
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