Cited 6 times in
Paracentric inversion-associated t(8;21) variant in de novo acute myelogenous leukemia: characteristic patterns of conventional cytogenetics, FISH, and multicolor banding analysis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 박용정 | - |
dc.contributor.author | 송재우 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 최종락 | - |
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2015-05-19T17:24:40Z | - |
dc.date.available | 2015-05-19T17:24:40Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108096 | - |
dc.description.abstract | Acute myelogenous leukemia (AML) with t(8;21)(q22;q22) demonstrates unique clinico-pathologic disease entity in patients with hematologic malignancies. The t(8;21), which results in fusion of the AML1 gene on 21q22 and the ETO gene on 8q22 on a molecular level, is one of the most common nonrandom chromosomal changes, and it is found in about 5-12% of patients with AML. Among these cases, complex variants involving chromosomes 8 and 21, as well as a third or fourth chromosome, account for approximately 6-10% of patients with an AML1/ETO chimeric gene, and about 100 variant cases with AML1/ETO fusion transcript have been reported in the literature. Here, we describe a rare case report of reciprocal paracentric inversion-associated t(8;21) variant in a 28-year old male patient with de novo AML. The abnormal results of conventional cytogenetics and interphase fluorescent in situ hybridization in this patient drove us to perform further studies and a literature review. This report emphasizes the value of "conventional" cytogenetics, as well as "newly developed" molecular cytogenetic methods in the diagnosis of rare complex t(8;21) variant in patients with AML. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CANCER GENETICS AND CYTOGENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Centromere/genetics* | - |
dc.subject.MESH | Chromosome Banding/methods | - |
dc.subject.MESH | Chromosome Inversion* | - |
dc.subject.MESH | Chromosomes, Human, Pair 21* | - |
dc.subject.MESH | Chromosomes, Human, Pair 8* | - |
dc.subject.MESH | Cytogenetic Analysis/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence/methods | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/diagnosis | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Translocation, Genetic* | - |
dc.title | Paracentric inversion-associated t(8;21) variant in de novo acute myelogenous leukemia: characteristic patterns of conventional cytogenetics, FISH, and multicolor banding analysis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Tae Sung Park | - |
dc.contributor.googleauthor | Jaewoo Song | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Yongjung Park | - |
dc.contributor.googleauthor | Juwon Kim | - |
dc.contributor.googleauthor | Eun Yup Lee | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2008.02.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A01582 | - |
dc.contributor.localId | A02054 | - |
dc.contributor.localId | A02647 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J00443 | - |
dc.identifier.eissn | 1873-4456 | - |
dc.identifier.pmid | 18474302 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460808001386 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Centromere/genetics* | - |
dc.subject.keyword | Chromosome Banding/methods | - |
dc.subject.keyword | Chromosome Inversion* | - |
dc.subject.keyword | Chromosomes, Human, Pair 21* | - |
dc.subject.keyword | Chromosomes, Human, Pair 8* | - |
dc.subject.keyword | Cytogenetic Analysis/methods* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | In Situ Hybridization, Fluorescence/methods | - |
dc.subject.keyword | Leukemia, Myeloid, Acute/diagnosis | - |
dc.subject.keyword | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Translocation, Genetic* | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Park, Yong Jung | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Park, Yong Jung | - |
dc.contributor.affiliatedAuthor | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 183 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 72 | - |
dc.citation.endPage | 76 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS AND CYTOGENETICS , Vol.183(1) : 72-76, 2008 | - |
dc.identifier.rimsid | 35180 | - |
dc.type.rims | ART | - |
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