Cited 89 times in
Effects of nattokinase on blood pressure: a randomized, controlled trial.
DC Field | Value | Language |
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dc.contributor.author | 박성하 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-05-19T17:22:43Z | - |
dc.date.available | 2015-05-19T17:22:43Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0916-9636 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108033 | - |
dc.description.abstract | The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1583~1588 | - |
dc.relation.isPartOf | HYPERTENSION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Dietary Supplements* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/blood | - |
dc.subject.MESH | Hypertension/diet therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Peptidyl-Dipeptidase A/blood | - |
dc.subject.MESH | Placebos | - |
dc.subject.MESH | Renin/blood | - |
dc.subject.MESH | Soy Foods* | - |
dc.subject.MESH | Subtilisins/administration & dosage* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effects of nattokinase on blood pressure: a randomized, controlled trial. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ji Young KIM | - |
dc.contributor.googleauthor | Si Nae GUM | - |
dc.contributor.googleauthor | Jean Kyung PAIK | - |
dc.contributor.googleauthor | Hyo Hee LIM | - |
dc.contributor.googleauthor | Kyong-Chol KIM | - |
dc.contributor.googleauthor | Kazuya OGASAWARA | - |
dc.contributor.googleauthor | Kenichi INOUE | - |
dc.contributor.googleauthor | Sungha PARK | - |
dc.contributor.googleauthor | Yangsoo JANG | - |
dc.contributor.googleauthor | Jong Ho LEE | - |
dc.identifier.doi | 10.1291/hypres.31.1583 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01017 | - |
dc.identifier.eissn | 1348-4214 | - |
dc.identifier.pmid | 18971533 | - |
dc.identifier.url | http://www.nature.com/hr/journal/v31/n8/full/hr2008203a.html | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Aged, 80 and over | - |
dc.subject.keyword | Blood Pressure | - |
dc.subject.keyword | Dietary Supplements* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hypertension/blood | - |
dc.subject.keyword | Hypertension/diet therapy* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Peptidyl-Dipeptidase A/blood | - |
dc.subject.keyword | Placebos | - |
dc.subject.keyword | Renin/blood | - |
dc.subject.keyword | Soy Foods* | - |
dc.subject.keyword | Subtilisins/administration & dosage* | - |
dc.subject.keyword | Treatment Outcome | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1583 | - |
dc.citation.endPage | 1588 | - |
dc.identifier.bibliographicCitation | HYPERTENSION RESEARCH, Vol.31(8) : 1583-1588, 2008 | - |
dc.identifier.rimsid | 50080 | - |
dc.type.rims | ART | - |
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