Cited 55 times in
Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: a case-control study.
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-05-19T17:22:36Z | - |
dc.date.available | 2015-05-19T17:22:36Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108029 | - |
dc.description.abstract | BACKGROUND: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a lipoprotein-bound enzyme that can release atherogenic isoprostanes from esterified phospholipids and that may be involved in inflammation and atherosclerosis. OBJECTIVE: This study investigates the association between Lp-PLA(2) activity and coronary artery disease (CAD) in relation to oxidative stress markers, in particular urinary 8-epi-prostaglandin F(2alpha) (8-epi-PGF(2alpha)). DESIGN: We conducted a case-control study in which the cross-sectional relation between Lp-PLA(2) activity, lipoproteins, and oxidative stress markers was determined in 799 patients with angiographically confirmed CAD and 925 healthy controls. RESULTS: Lp-PLA(2) activity was significantly (P < 0.001) higher in CAD cases than in controls (32.9 +/- 0.46 and 29.7 +/- 0.42 nmol . mL(-1) . min(-1), respectively). Both elevated Lp-PLA(2) activity and urinary excretion concentrations of 8-epi-PGF(2alpha) were associated with greater CAD risk (P for trend < 0.001). Odds ratios for the upper quartiles of Lp-PLA(2) activity and 8-epi-PGF(2alpha).excretion were 2.47 (95% CI: 1.79, 3.40) and 2.19 (1.52, 3.15), respectively, after adjustment for sex, age, BMI, blood pressure, smoking and alcohol consumption status, and LDL and HDL cholesterol. When we examined the additive effect of both markers for CAD risk, the relation between 8-epi-PGF(2alpha) and CAD was weakened above the second quartile of Lp-PLA(2) activity. Moreover, Lp-PLA(2) activity was positively correlated with urinary excretion concentrations of 8-epi-PGF(2alpha) in controls (r = 0.277, P < 0.001) and cases (r = 0.202, P < 0.001) and with the tail moment of lymphocyte DNA (r = 0.213, P < 0.001) in controls. CONCLUSION: This study shows an association of elevated Lp-PLA(2) activity with CAD risk in relation to oxidant stress and thus supports a proatherogenic role of Lp-PLA(2). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 630~637 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CLINICAL NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | C-Reactive Protein/metabolism* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Coronary Disease/blood* | - |
dc.subject.MESH | Coronary Disease/enzymology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Life Style | - |
dc.subject.MESH | Lipoproteins, LDL/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxidative Stress* | - |
dc.subject.MESH | Reference Values | - |
dc.title | Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: a case-control study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Yae Jung Hyun | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Byoung Kwon Lee | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | So Eui Kim | - |
dc.contributor.googleauthor | Hyun Yang Yeo | - |
dc.contributor.googleauthor | Tae-Sook Jeong | - |
dc.contributor.googleauthor | Dong Woon Jeon | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1093/ajcn/88.3.630 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00074 | - |
dc.identifier.eissn | 1938-3207 | - |
dc.identifier.pmid | 18779277 | - |
dc.subject.keyword | 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood* | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Aged, 80 and over | - |
dc.subject.keyword | Biomarkers/blood | - |
dc.subject.keyword | C-Reactive Protein/metabolism* | - |
dc.subject.keyword | Case-Control Studies | - |
dc.subject.keyword | Coronary Disease/blood* | - |
dc.subject.keyword | Coronary Disease/enzymology* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Life Style | - |
dc.subject.keyword | Lipoproteins, LDL/blood | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Oxidative Stress* | - |
dc.subject.keyword | Reference Values | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 88 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 630 | - |
dc.citation.endPage | 637 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol.88(3) : 630-637, 2008 | - |
dc.identifier.rimsid | 50077 | - |
dc.type.rims | ART | - |
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