5 299

Cited 38 times in

The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.

DC FieldValueLanguage
dc.contributor.author박성하-
dc.contributor.author안철민-
dc.contributor.author장양수-
dc.date.accessioned2015-05-19T17:22:02Z-
dc.date.available2015-05-19T17:22:02Z-
dc.date.issued2008-
dc.identifier.issn0009-8981-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108011-
dc.description.abstractBACKGROUND: Concentrations of adiponectin, the protein product of the adipocyte C1q and collagen-domain-containing (ADIPOQ) gene are associated with type 2 diabetes and coronary artery disease. We investigate the association of single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene with adiponectin concentrations, and to parameters of metabolic syndrome. METHODS: 867 unrelated, non-diabetic Korean women, 20 to 69 y, were genotyped for 8 SNPs in the ADIPOQ gene (-11391G>A, -11377C>G, H241P, Y111H, G90S, R221S, 45T>G, 276G>T). Adiponectin, a homeostasis model assessment of insulin resistance (HOMA-IR), and metabolic parameters were measured. RESULTS: Carriers of genotype T/T at position 276 had significantly higher adiponectin concentrations than G/G carriers (P=0.005). Homozygous carriers of the TG haplotype (i.e., individuals who were T/T at 45 and G/G at 276) and heterozygous carriers of the TG haplotype (TG/X) had lower adiponectin concentrations than non-TG carriers (P<0.001). Significant associations between SNP at 276 and serum concentrations of triglyceride (P=0.013), insulin (P=0.013) and HOMA-IR (P=0.012) were found. The 45-276 haplotypes had associations identical to the 276G>T SNP. In subgroup analysis, subjects carrying the TG haplotype had significantly lower adiponectin concentrations than non-TG carriers in both normal weight (P<0.001) and overweight-obese (P=0.009) subgroups. The association of the TG haplotype with increasing insulin concentrations was significant among overweight-obese subjects (P=0.004), but was not significant among normal weight subjects. A similar association was found between the 45-276 haplotype and HOMA-IR. CONCLUSION: There is a strong association of the adiponectin SNP276 genotypes and the adiponectin 45-276 haplotypes with circulating adiponectin concentrations in non-diabetic Korean women. In addition, this haplotype is associated with increased insulin concentrations and insulin resistance index only in overweight-obese individuals.-
dc.description.statementOfResponsibilityopen-
dc.format.extent85~90-
dc.relation.isPartOfCLINICA CHIMICA ACTA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/blood*-
dc.subject.MESHAdiponectin/genetics*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHaplotypes-
dc.subject.MESHHumans-
dc.subject.MESHInsulin/blood-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHMetabolic Syndrome/blood-
dc.subject.MESHMetabolic Syndrome/epidemiology-
dc.subject.MESHMetabolic Syndrome/genetics*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHTriglycerides/blood-
dc.titleThe influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorJey Sook Chae-
dc.contributor.googleauthorSoo Jeong Koh-
dc.contributor.googleauthorYae Jung Hyun-
dc.contributor.googleauthorJi Young Kim-
dc.contributor.googleauthorYeo Jin Jeong-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorChul-Min Ahn-
dc.contributor.googleauthorJong Ho Lee-
dc.identifier.doi10.1016/j.cca.2008.02.011-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01512-
dc.contributor.localIdA02269-
dc.contributor.localIdA03448-
dc.relation.journalcodeJ00543-
dc.identifier.eissn1873-3492-
dc.identifier.pmid18328815-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0009898108000764-
dc.subject.keywordAdipocyte C1q and collagen domain-containing (ADIPOQ)-
dc.subject.keywordAdiponectin-
dc.subject.keywordSingle nucleotide polymorphism (SNP)-
dc.subject.keywordInsulin-
dc.subject.keywordHomeostasis model assessment of insulin resistance (HOMA-IR)-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameAhn, Chul Min-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorAhn, Chul Min-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.rights.accessRightsnot free-
dc.citation.volume391-
dc.citation.number1-2-
dc.citation.startPage85-
dc.citation.endPage90-
dc.identifier.bibliographicCitationCLINICA CHIMICA ACTA, Vol.391(1-2) : 85-90, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.