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Inhibitory Effect of Ethyl Acetate Extract of White Peach Pericarp on Adipogenesis of 3T3-L1 Preadipocyte Cells

Authors
 Hong Gyu Park  ;  Jin Moon Kim  ;  Jung Mogg Kim  ;  Won-Yoon Chung  ;  Yun-Jung Yoo  ;  Jeong-Heon Cha 
Citation
 FOOD SCIENCE AND BIOTECHNOLOGY, Vol.17(6) : 1327-1331, 2008 
Journal Title
 FOOD SCIENCE AND BIOTECHNOLOGY 
ISSN
 1226-7708 
Issue Date
2008
Keywords
Prunus persica ; peach ; obesity ; C3H10T1/2 ; 3T3-L1
Abstract
In order to determine whether peach contains compounds to regulate adipocyte differentiation, extracts of flesh/pericarp of yellow/white peach were prepared in water, ethyl acetate (EtOAc), or n-butanol solvent and determined for effects on adipocyte differentiation in C3H10T1/2 or 3T3-L1 cells. Interestingly, none of peach extracts has statistically significant stimulatory effect on the adipocyte differentiation in C3H10T1/2. Furthermore, the presence of EtOAc extract of white peach pericarp (WPP) was found to inhibit lipid accumulation in 3T3-L1 cells both by microscopic examination of Oil Red Ostained lipid droplets and by spectrophotometric quantification of extracted stain, indicating a significant inhibitory effect on adipocyte differentiation. The inhibition of lipid accumulation was accompanied by a significant decrease in the expression levels of adipocyte molecular markers-peroxisome proliferator-activated receptor γ, CAAT enhancer binding protein α, and fatty acid-binding protein. Thus, this study determined that WPP EtOAc extract contains the inhibitory compound(s) on adipogenesis.
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Moon(김진문)
Park, Hong Gyu(박홍규)
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
Cha, Jeong Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107995
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