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프로테오믹스를 이용한 경직성 뇌성마비 환자의 근조직 내 DJ-1 발현 분석

Other Titles
 Proteomic Analysis of DJ-1 Expression in the Muscles of Spastic Cerebral Palsy Patients 
 곽윤해  ;  한수봉  ;  공선영  ;  홍승우  ;  김현우 
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지), Vol.11(2) : 45-55, 2008 
Journal Title
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지) 
Issue Date
Cerebral palsy ; Muscles ; Proteomic analysis ; DJ-1
PURPOSE: Using proteomic analysis, this study was performed to see the characteristics of proteins expression in the muscles of spastic cerebral palsy patients. MATERIALS AND METHODS: We studied twelve specimens from six patients with spastic cerebral palsy, three patients with myelomeningocele, and three normal people who underwent orthopaedic surgeries due to trauma. We studied the extracted proteins showing differences in the two-dimensional electrophoresis, and the prominent thirteen proteins were re-evaluated by proteomics and the reverse transcriptional polymerase chain reaction, which was to clarify the relationship between gene and protein expression. RESULTS: Among fifteen proteins, six proteins were found to be higher in normal people, and nine were found to be higher in the groups of patients by spot histogram. The results of proteomic analysis with MALDI-TOF for fifteen proteins showed that the expression of DJ-1 was related to cerebral palsy. CONCLUSION: This study shows that strong expression of DJ-1 is related to spasticity and cerebral palsy. We showed for the first time the possibility of any relationship between spastic condition and DJ-1 expression.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Yoon Hae(곽윤해) ORCID logo https://orcid.org/0000-0002-0596-1228
Kim, Hyun Woo(김현우) ORCID logo https://orcid.org/0000-0001-8576-1877
Hahn, Soo Bong(한수봉)
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