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Heat Shock Protein 90 Regulates Angiotensin II-induced Vascular Smooth Muscle Cell Hypertrophy through STAT1 Nuclear Translocation and IL-6 Release

Authors
 Jae Won Oh  ;  Kyung Hye Lee  ;  Seok Min Kang  ;  Ki Chul Hwang  ;  Yang Soo Jang  ;  Ji Hyung Chung 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.5(4) : 910-917, 2008 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학)
ISSN
 1738-2696 
Issue Date
2008
Keywords
Cell hypertrophy ; hsp90 ; angiotensin 2
Abstract
Heat shock protein 90(Hsp90), one of the most abundant proteins in the eukaryotic cells, is essential for cell survival and its contribution to various cellular processes, including signal transduction has been extensively studied. Hsp90 is also abundant in vascular smooth muscle cells(VSMCs), but its function is largely unknown. In this study, we have investigated the role of Hsp90 in angiotensin II(Ang II)-induced VSMC hypertrophy. An Hsp90- specific inhibitor geldanamycin(GA) abolished Ang II-induced [3H]leucine incorporation levels and decreased the ration of total protein to DNA content in a concentration dependentmanner in VSMCs. In addition, GA significantly suppressed Ang II-induced STAT1 nuclear translocation and IL-6 production. Furthermore, treatment of IL-6-neutralizing antibody decreased Ang II-induced hypertrophy in VSMCs. We also demonstrated that intracellular delivery of Hsp90 significantly restored Ang II-induced hypertrophyin VSMCs. These results suggest Ang II inducesVSMC hypertrophy partly through STAT1 nuclear translocation, IL-6 release and autocrine VSMC activation, and it is regulated by Hsp90
Full Text
http://search.koreanstudies.net/journal/thesis_name.asp?tname=kiss2002&key=3118964
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107944
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