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Mannitol의 주입 경로와 양 및 농도가 혈-뇌 장벽 손상에 미치는 효과

Other Titles
 Effects of injection route, volume and concentration of mannitol on blood-brain barrier disruption 
 차명훈  ;  이규홍  ;  이철현  ;  정명애  ;  손진훈  ;  정재준  ;  이배환 
 Korean Journal of the Science of Emotion & Sensibility (감성과학), Vol.11(4) : 565-574, 2008 
Journal Title
Korean Journal of the Science of Emotion & Sensibility(감성과학)
Issue Date
Functions of human brain including sensibility and emotion may be affected by drugs mediated by the blood-brain barrier (BBB). The present study was performed to evaluate whether injection route, volume and concentration of mannitol could alter the degree of disruption of the BBB. Under urethane anesthesia, female Sprague-Dawley rats were infused with 20% mannitol into the right internal carotid artery (ICA). In the other group, intravenous injection of mannitol through the femoral vein was performed. Evans blue(EB) dye was used as a marker of BBB disruption. When mannitol was injected via the ICA, the content of EB dye in the ipsilateral hemisphere was markedly increased. However, the content of EB in the brain was not increased when mannitol was injected via the femoral vein, even though the volume or concentration of mannitol was increased. These results suggest that the BBB was disrupted only through ICA injection route and this may provide a useful strategy for transient opening of the BBB to control the functions of human brain
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
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