471 195

Cited 14 times in

Effect of a ketogenic diet on EEG: Analysis of sample entropy

Authors
 Myung-Kul Yum  ;  Ki-Young Jung  ;  Hoon-Chul Kang  ;  Heung Dong Kim  ;  Young-Min Shon  ;  Joong-Ku Kang  ;  Il Keun Lee  ;  Ki-Jong Park  ;  Oh-Young Kwon 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.17(6) : 561-566, 2008 
Journal Title
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 
ISSN
 1059-1311 
Issue Date
2008
MeSH
Analysis of Variance ; Child, Preschool ; Electroencephalography* ; Entropy* ; Female ; Follow-Up Studies ; Humans ; Ketones/therapeutic use* ; Male ; Retrospective Studies ; Seizures/diet therapy* ; Seizures/physiopathology*
Keywords
Ketogenic diet ; EEG ; Sample entropy ; Anticonvulsive mechanism ; Therapeutic responsiveness
Abstract
Although ketogenic diet (KD) is an effective alternative therapy for controlling intractable seizures, the anticonvulsant mechanism still remains unclear. Sample entropy (SampEn) provides a generalized measure of regularity in time-series data. To investigate the potential anticonvulsive mechanism of a KD, we analyzed the SampEn of electroencephalography (EEG) data in patients with intractable pediatric epilepsy before and after treatment with a KD. Seventeen pediatric patients with epilepsy who were treated with KD were enrolled in present study. Patients were classified as good responder and poor responder according to therapeutic responsiveness on KD. Thirty segments of 30-s epochs were selected before and after KD from each patient which were subject to SampEn. The KD increased the SampEn in the whole patient population; the SampEn increased significantly in all electrodes in the good responders, but the change in SampEn varied according to the electrode in the poor responders. Before the KD, the good responders had significantly lower SampEn values than the poor responders, but after the KD, SampEn values were higher in the good responders than in the poor responders. KD may have an anticonvulsive effect by decreasing the regularity of the EEG dynamics.
Files in This Item:
T200801595.pdf Download
DOI
10.1016/j.seizure.2008.02.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107929
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse