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A case of black thyroid associated with hyalinizing trabecular tumor

Authors
 Sang-Wook KANG  ;  Soon Won HONG  ;  Pyo Ju YEON  ;  Jong Ju JEONG  ;  Tae Yon SUNG  ;  Seung Chul LEE  ;  Yong Sang LEE  ;  Kee-Hyun NAM  ;  Woong Youn CHUNG  ;  Hang Seok CHANG  ;  Cheong Soo PARK 
Citation
 ENDOCRINE JOURNAL, Vol.55(6) : 1109-1112, 2008 
Journal Title
ENDOCRINE JOURNAL
ISSN
 0918-8959 
Issue Date
2008
MeSH
Adenoma/diagnosis* ; Adenoma/metabolism ; Adenoma/physiopathology ; Adult ; Female ; Humans ; Hyalin/metabolism ; Pigmentation/physiology* ; Thyroid Gland/physiopathology* ; Thyroid Neoplasms/diagnosis* ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/physiopathology
Keywords
Black thyroid ; Hyalinizing trabecular tumor ; Minocycline
Abstract
Black thyroid is an uncommon phenomenon of black pigmentation of thyroid parenchyma induced by chronic minocycline therapy. Thyroid tumors associated with black pigmented thyroid are rare. We describe here a 42-year-old woman with a black thyroid associated with hyalinizing trabecular tumor (HTT). The patient presented with a palpable left-sided thyroid nodule. She had taken minocycline for aphthous stomatitis and an oral ulcer for 9 years. The findings of fine needle aspiration biopsy and BRAF mutation analysis suggested a papillary carcinoma. The patient underwent a near-total thyroidectomy with central compartment node dissection. The surgical specimen showed a diffuse black thyroid and a 2-cm non-pigmented, well-circumscribed nodule in the left thyroid. Histopathologically, numerous black pigmented follicular epithelial cells and colloid were seen throughout the thyroid parenchyma, and the nodule was composed of elongated, polygonal cells in trabecular arrangement and dense hyaline stromas. The tumor cells showed a strong positive cytoplasmic reaction to Ki 67. All of these findings suggested a HTT, or a hyalinizing trabecular variant of papillary carcinoma, arising in a black thyroid. To our knowledge, this is the first case of black thyroid associated with HTT
Files in This Item:
T200801559.pdf Download
DOI
18753707
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Sung, Tae Yon(성태연)
Lee, Seung Chul(이승철)
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107891
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