Cited 30 times in
Postoperative intravenous patient-controlled analgesia in thyroid surgery: comparison of fentanyl and ondansetron regimens with and without the nonsteriodal anti-inflammatory drug ketorolac
DC Field | Value | Language |
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dc.contributor.author | 김기준 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 남기현 | - |
dc.contributor.author | 장동진 | - |
dc.date.accessioned | 2015-05-19T17:17:11Z | - |
dc.date.available | 2015-05-19T17:17:11Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1050-7256 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107857 | - |
dc.description.abstract | BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs), through synergistic action with opioids, can reduce postoperative nausea and vomiting via intravenous patient-controlled analgesia (PCA). We compared the efficacy of three PCA regimens. METHODS: Patients (n = 135) undergoing thyroidectomy were randomly allocated to three PCA regimens. All groups received 12 mg ondansetron (a serotonin 5-HT(3) receptor antagonist). In addition, Group I received the opioid fentanyl, 15 microg/kg. Group II received fentanyl 12.5 microg/kg and the NSAID ketorolac, 1.5 mg/kg, and Group III received fentanyl 10 microg/kg and ketorolac 3 mg/kg. Pain scores, nausea and vomiting, and dizziness were assessed 1, 6, 12, and 24 hours postoperatively. RESULTS: Pain scores were similar among the three groups. However, postoperative nausea and vomiting was significantly lower in groups II and III (p < 0.05) than group I. Postoperative dizziness was significantly lower in group III than groups I and II (p < 0.05). CONCLUSIONS: The NSAID ketorolac when combined with lower doses of the opioid fentanyl and the same dose of ondansetron is associated with the same analgesic efficacy but less nausea and vomiting after thyroid surgery. A higher ratio of NSAID to opioid, when used as reported here, is associated with less postoperative dizziness. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1285~1290 | - |
dc.relation.isPartOf | THYROID | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Analgesia, Patient-Controlled/methods* | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/therapeutic use* | - |
dc.subject.MESH | Dizziness/drug therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fentanyl/administration & dosage | - |
dc.subject.MESH | Fentanyl/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Ketorolac/administration & dosage | - |
dc.subject.MESH | Ketorolac/therapeutic use* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ondansetron/administration & dosage | - |
dc.subject.MESH | Ondansetron/therapeutic use* | - |
dc.subject.MESH | Pain, Postoperative/drug therapy* | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/drug therapy* | - |
dc.subject.MESH | Thyroidectomy | - |
dc.title | Postoperative intravenous patient-controlled analgesia in thyroid surgery: comparison of fentanyl and ondansetron regimens with and without the nonsteriodal anti-inflammatory drug ketorolac | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Eun Mi Kim | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.contributor.googleauthor | Dong Jin Chang | - |
dc.contributor.googleauthor | Sun Ho Nam | - |
dc.contributor.googleauthor | Ki Jun Kim | - |
dc.identifier.doi | 10.1089/thy.2008.0007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00340 | - |
dc.contributor.localId | A01245 | - |
dc.contributor.localId | A03427 | - |
dc.contributor.localId | A00616 | - |
dc.relation.journalcode | J02729 | - |
dc.identifier.eissn | 1557-9077 | - |
dc.identifier.pmid | 18976162 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/thy.2008.0007 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Analgesia, Patient-Controlled/methods* | - |
dc.subject.keyword | Anti-Inflammatory Agents, Non-Steroidal/therapeutic use* | - |
dc.subject.keyword | Dizziness/drug therapy | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Fentanyl/administration & dosage | - |
dc.subject.keyword | Fentanyl/therapeutic use* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Injections, Intravenous | - |
dc.subject.keyword | Ketorolac/administration & dosage | - |
dc.subject.keyword | Ketorolac/therapeutic use* | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Ondansetron/administration & dosage | - |
dc.subject.keyword | Ondansetron/therapeutic use* | - |
dc.subject.keyword | Pain, Postoperative/drug therapy* | - |
dc.subject.keyword | Postoperative Nausea and Vomiting/drug therapy* | - |
dc.subject.keyword | Thyroidectomy | - |
dc.contributor.alternativeName | Kim, Ki Jun | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Nam, Kee Hyun | - |
dc.contributor.alternativeName | Chang, Dong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Ki Jun | - |
dc.contributor.affiliatedAuthor | Nam, Kee Hyun | - |
dc.contributor.affiliatedAuthor | Chang, Dong Jin | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1285 | - |
dc.citation.endPage | 1290 | - |
dc.identifier.bibliographicCitation | THYROID, Vol.18(12) : 1285-1290, 2008 | - |
dc.identifier.rimsid | 34732 | - |
dc.type.rims | ART | - |
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