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Association of abdominal obesity with atherosclerosis in Type 2 diabetes mellitus (T2DM) in Korea

Authors
 Minho Cho  ;  Jong Suk Park  ;  Jisun Nam  ;  Chul Sik Kim  ;  Jae Hyun Nam  ;  Hai Jin Kim  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Sung Kil Lim  ;  Kyung Rae Kim  ;  Hyun Chul Lee  ;  Kap Bum Huh 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.23(5) : 781-788, 2008 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2008
MeSH
Aged ; Atherosclerosis/complications ; Blood Pressure ; Coronary Vessels/pathology ; Diabetes Complications ; Diabetes Mellitus, Type 2/genetics* ; Female ; Humans ; Insulin Resistance ; Korea ; Male ; Middle Aged ; Obesity/complications* ; Obesity/genetics* ; Triglycerides/metabolism ; Tunica Intima/pathology ; Tunica Media/pathology
Keywords
Obesity ; Insulin Resistance ; Diabetes Mellitus Type 2 ; Atherosclerosis
Abstract
The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDLC), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients
Files in This Item:
T200801528.pdf Download
DOI
10.3346/jkms.2008.23.5.781
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Chul Sik(김철식)
Nam, Jae Hyun(남재현)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cho, Min Ho(조민호)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Huh, Kap Bum(허갑범)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107851
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