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Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible

 J-Y Kim  ;  S-T Kim  ;  S-W Cho  ;  H-S Jung  ;  K-T Park  ;  H-K Son 
 ORAL DISEASES, Vol.14(7) : 626-632, 2008 
Journal Title
Issue Date
Animals ; Apoptosis ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/pharmacology* ; Cartilage, Articular/drug effects ; Injections, Intramuscular ; Male ; Mandible/drug effects* ; Mandible/growth & development ; Mandibular Condyle/drug effects ; Masseter Muscle/drug effects ; Maxillofacial Development/drug effects* ; Rats ; Rats, Sprague-Dawley
botulinum toxin type A ; masseter muscle ; rat mandible ; condylar cartilage.
OBJECTIVES: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. MATERIALS AND METHODS: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. RESULTS: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. CONCLUSIONS: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Taek(김성택)
Son, Heung Kyu(손흥규)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
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