Cited 12 times in
Modulation of matrix metalloproteinase secretion by adenosine A3 receptor in preeclamptic villous explants.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김영한 | - |
dc.contributor.author | 박용원 | - |
dc.date.accessioned | 2015-05-19T17:16:12Z | - |
dc.date.available | 2015-05-19T17:16:12Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1933-7191 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107826 | - |
dc.description.abstract | The impairment of trophoblast invasion associated with preeclampsia may involve matrix metalloproteinase (MMP). Adenosine A3 receptors expression in trophoblast is upregulated in preeclampsia. This study was designed to determine if A3 receptors modulate MMP secretion in villous explants from preeclamptic pregnancies. Villous explants from normal and preeclamptic pregnancies were cultured at 20% and 3% oxygen. There were significantly increased A3 receptor and reduced MMP-2/-9 expression at low oxygen level in normal and preeclamptic explants. Interestingly, in preeclamptic explants, after high oxygen culture, the expression of MMP-2/-9 were recovered to almost same level of those in normal explants. Treatment of preeclamptic explants with A3 receptor agonist in low oxygen level resulted in an enhanced expression of MMP-2/-9 in a time- and dose-dependent manner. In summary, this study indicates that trophoblastic adenosine A3 receptors are 1) modulated by oxygen tension, and 2) regulate MMP-2/-9 expression | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 939~949 | - |
dc.relation.isPartOf | REPRODUCTIVE SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenosine A3 Receptor Agonists | - |
dc.subject.MESH | Chorionic Villi/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Matrix Metalloproteinases/metabolism* | - |
dc.subject.MESH | Pre-Eclampsia/enzymology | - |
dc.subject.MESH | Pre-Eclampsia/metabolism* | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Receptor, Adenosine A3/metabolism* | - |
dc.subject.MESH | Tissue Inhibitor of Metalloproteinases/metabolism | - |
dc.subject.MESH | Trophoblasts/metabolism | - |
dc.title | Modulation of matrix metalloproteinase secretion by adenosine A3 receptor in preeclamptic villous explants. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Young-Han Kim | - |
dc.contributor.googleauthor | Han-Sung Hwang | - |
dc.contributor.googleauthor | Young-Tae Kim | - |
dc.contributor.googleauthor | Haeng-Soo Kim | - |
dc.contributor.googleauthor | Yong-Won Park | - |
dc.identifier.doi | 10.1177/1933719108322431 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A00730 | - |
dc.contributor.localId | A01581 | - |
dc.relation.journalcode | J02606 | - |
dc.identifier.eissn | 1933-7205 | - |
dc.identifier.pmid | 19050327 | - |
dc.identifier.url | http://rsx.sagepub.com/content/15/9/939.long | - |
dc.subject.keyword | adenosine A3 receptor | - |
dc.subject.keyword | matrix metalloproteinase | - |
dc.subject.keyword | preeclampsia | - |
dc.subject.keyword | villous explants. | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Young Han | - |
dc.contributor.alternativeName | Park, Yong Won | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Kim, Young Han | - |
dc.contributor.affiliatedAuthor | Park, Yong Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 939 | - |
dc.citation.endPage | 949 | - |
dc.identifier.bibliographicCitation | REPRODUCTIVE SCIENCES, Vol.15(9) : 939-949, 2008 | - |
dc.identifier.rimsid | 34710 | - |
dc.type.rims | ART | - |
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