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정상 산모와 중증 전자간증 산모의 태반에서 Matrix Metalloproteinase (MMP) -2, -9의 발현양상
DC Field | Value | Language |
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dc.contributor.author | 권자영 | - |
dc.contributor.author | 김영한 | - |
dc.contributor.author | 박용원 | - |
dc.date.accessioned | 2015-05-19T17:14:36Z | - |
dc.date.available | 2015-05-19T17:14:36Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1738-5628 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107775 | - |
dc.description.abstract | Objective: The aim of the study was to investigate the differential expression of Matrix Metalloproteinase (MMP) -2,-9 in the normal and severe preeclamptic placenta. Methods: Placentas were obtained from women undergoing cesarean section with normal (n=10) and severe preeclamptic (n=10) pregnancies. Semi-quantitative RT-PCR was done to detect the placental gene expression of MMP-2,-9. Western blot analysis was performed to identify MMP-2,-9 protein expression in each placenta. Immunohistochemical staining were employed to localize MMP-2,-9 in placental tissues. Results: MMP-2,-9 genes were expressed in both normal and severe preeclamptic placenta. There were lower expressions MMP-2,-9 in severe preeclamptic placentas than in normal. MMP-2,-9 proteins were all present in each placental tissue. The expression for MMP-2,-9 was weaker in severe preeclamptic placenta than in normal. MMP-2,-9 were localized only to the trophoblast, and were also weakly positive in severe preeclamptic placenta compared with normal. Conclusions: MMP-2,-9 expressions were decreased in severe preeclampsia placenta compared to those from normal placenta. This study suggests that decreased expression of MMP-2,-9 may have a role in the development of severe preeclampsia | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1245~1253 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 정상 산모와 중증 전자간증 산모의 태반에서 Matrix Metalloproteinase (MMP) -2, -9의 발현양상 | - |
dc.title.alternative | Differential expression of Matrix Metalloproteinase (MMP)-2, -9 in normal and severe preeclamptic human placentas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | 문여정 | - |
dc.contributor.googleauthor | 황한성 | - |
dc.contributor.googleauthor | 김영한 | - |
dc.contributor.googleauthor | 권자영 | - |
dc.contributor.googleauthor | 박용원 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00246 | - |
dc.contributor.localId | A00730 | - |
dc.contributor.localId | A01581 | - |
dc.relation.journalcode | J02076 | - |
dc.identifier.pmid | MMP-2; MMP-9; Severe preeclampsia; Placenta | - |
dc.subject.keyword | MMP-2 | - |
dc.subject.keyword | MMP-9 | - |
dc.subject.keyword | Severe preeclampsia | - |
dc.subject.keyword | Placenta | - |
dc.contributor.alternativeName | Kwon, Ja Young | - |
dc.contributor.alternativeName | Kim, Young Han | - |
dc.contributor.alternativeName | Park, Yong Won | - |
dc.contributor.affiliatedAuthor | Kwon, Ja Young | - |
dc.contributor.affiliatedAuthor | Kim, Young Han | - |
dc.contributor.affiliatedAuthor | Park, Yong Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 51 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1245 | - |
dc.citation.endPage | 1253 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.51(11) : 1245-1253, 2008 | - |
dc.identifier.rimsid | 34674 | - |
dc.type.rims | ART | - |
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