Cited 59 times in
Replicative senescence induced by Romo1-derived reactive oxygen species.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형중 | - |
dc.date.accessioned | 2015-05-19T17:13:51Z | - |
dc.date.available | 2015-05-19T17:13:51Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107751 | - |
dc.description.abstract | Persistent accumulation of DNA damage induced by reactive oxygen species (ROS) is proposed to be a major contributor toward the aging process. Furthermore, an increase in age-associated ROS is strongly correlated with aging in various species, including humans. Here we showed that the enforced expression of the ROS modulator 1 (Romo1) triggered premature senescence by ROS production, and this also contributed toward induction of DNA damage. Romo1-derived ROS was found to originate in the mitochondrial electron transport chain. Romo1 expression gradually increased in proportion to population doublings of IMR-90 human fibroblasts. An increase in ROS production in these cells with high population doubling was blocked by the Romo1 knockdown using Romo1 small interfering RNA. Romo1 knockdown also inhibited the progression of replicative senescence. Based on these results, we suggest that age-related ROS levels increase, and this contributes to replicative senescence, which is directly associated with Romo1 expression | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33763~33771 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cellular Senescence/physiology* | - |
dc.subject.MESH | DNA Damage/physiology* | - |
dc.subject.MESH | Electron Transport Chain Complex Proteins/metabolism | - |
dc.subject.MESH | Fibroblasts/cytology | - |
dc.subject.MESH | Fibroblasts/metabolism* | - |
dc.subject.MESH | Gene Expression Regulation/physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Membrane Proteins/biosynthesis* | - |
dc.subject.MESH | Membrane Proteins/genetics | - |
dc.subject.MESH | Mitochondrial Proteins/biosynthesis* | - |
dc.subject.MESH | Mitochondrial Proteins/genetics | - |
dc.subject.MESH | RNA, Small Interfering | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.title | Replicative senescence induced by Romo1-derived reactive oxygen species. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young Min Chung | - |
dc.contributor.googleauthor | Seung Baek Lee | - |
dc.contributor.googleauthor | Hyung Jung Kim | - |
dc.contributor.googleauthor | Seon Ho Park | - |
dc.contributor.googleauthor | Jung Jin Kim | - |
dc.contributor.googleauthor | Jin Sil Chung | - |
dc.contributor.googleauthor | Young Do Yoo | - |
dc.identifier.doi | 10.1074/jbc.M805334200 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01158 | - |
dc.relation.journalcode | J01258 | - |
dc.identifier.eissn | 1083-351X | - |
dc.identifier.pmid | 18836179 | - |
dc.subject.keyword | Cell Line | - |
dc.subject.keyword | Cellular Senescence/physiology* | - |
dc.subject.keyword | DNA Damage/physiology* | - |
dc.subject.keyword | Electron Transport Chain Complex Proteins/metabolism | - |
dc.subject.keyword | Fibroblasts/cytology | - |
dc.subject.keyword | Fibroblasts/metabolism* | - |
dc.subject.keyword | Gene Expression Regulation/physiology* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Membrane Proteins/biosynthesis* | - |
dc.subject.keyword | Membrane Proteins/genetics | - |
dc.subject.keyword | Mitochondrial Proteins/biosynthesis* | - |
dc.subject.keyword | Mitochondrial Proteins/genetics | - |
dc.subject.keyword | RNA, Small Interfering | - |
dc.subject.keyword | Reactive Oxygen Species/metabolism* | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Kim, Hyung Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 283 | - |
dc.citation.number | 48 | - |
dc.citation.startPage | 33763 | - |
dc.citation.endPage | 33771 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.283(48) : 33763-33771, 2008 | - |
dc.identifier.rimsid | 55305 | - |
dc.type.rims | ART | - |
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