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Interactive effect of central obesity and hypertension on cognitive function in older out-patients with Type 2 diabetes

 E. Kim  ;  M. H. Cho  ;  K. R. Cha  ;  J. S. Park  ;  C-W. Ahn  ;  B. H. Oh  ;  C-H. Kim 
 DIABETIC MEDICINE, Vol.25(12) : 1440-1446, 2008 
Journal Title
Issue Date
Aged ; Cognition Disorders/etiology* ; Diabetes Mellitus, Type 2/psychology* ; Female ; Geriatric Assessment ; Humans ; Hypertension/psychology* ; Male ; Middle Aged ; Obesity/psychology* ; Psychomotor Disorders/etiology ; Psychophysiologic Disorders/etiology ; Risk Factors
central obesity ; cognitive function ; elderly ; hypertension ; Type 2 diabetes
AIM: Central obesity, hypertension and diabetes mellitus have been related individually to cognitive dysfunction. We aimed to study the interactive effects of these co-occurring risk factors on cognitive decline, which remain unclear in older patients with diabetes. METHODS: We assessed metabolic profiles and neuropsychological functions in 60 older out-patients with Type 2 diabetes to examine the associations of central obesity with cognitive functions, while controlling for other confounding factors in these subjects. RESULTS: Waist circumference was associated with poor performance in digits forward (r2 = 0.11, P = 0.02), choice reaction time (r2 = 0.08, P = 0.04) and cognitive reaction time (r2 = 0.07, P < 0.05) even after adjustment for potential confounders including age, gender, education and HbA1c. There were also significant interactions between central obesity and hypertension with respect to performance of digits forward (P = 0.04) and delayed verbal cued recall (P = 0.03). CONCLUSION: Our findings suggest that, in addition to glycaemic control, central obesity and hypertension influence cognitive functions, such as attention and psychomotor speed in older patients with Type 2 diabetes.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eosu(김어수) ORCID logo https://orcid.org/0000-0001-9472-9465
Kim, Chan Hyung(김찬형)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Oh, Byong Hoon(오병훈)
Cho, Min Ho(조민호)
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